Our mission at the MSk Lab Clinical Trials is to assure excellence, efficiency, and transparency in the design, conduct, analysis, and reporting of clinical trials for the benefit of patients and society.
We collaborate with researchers to design, conduct, analyse, and publish clinical trials and other well-designed studies for musculoskeletal disorders.

Our portfolio of studies includes the following current trials:

Furlong Evolution®

Furlong Evolution® Hip Trail

This is a multicentre clinical trial of CE marked devices, such as the Furlong Evolution® Hip Trial, with centers around the UK.

Gait Analysis of Lower Limb Surgical Patients

Gait Analysis of Lower Limb Surgical Patients

In this trial, we are investigating the differences in gait patterns between different kinds of hip and knee arthroplasties.

H1 Hip Resurfacing Arthroplasty

H1 Hip Resurfacing Arthroplasty

The primary objective of this study is to confirm the safety and efficacy of the H1 implant by demonstrating non-inferiority compared to the Birmingham Hip Resurfacing (where revision of the device is deemed a failure). The secondary objective is to demonstrate the superiority of the H1 Implant with its metal-free articulation compared to metal-on-metal hip resurfacing in the absence of metal ion release.The H1 implant is designed and manufactured by Embody Orthopaedics.

Imperial Orthopaedic Score Validation Study

Imperial Orthopaedic Score Validation Study

This is a mixed study design consisting of a qualitative focus group, expert opinion, and a quantitative cohort study. The aims of the research are twofold. Firstly, to develop a robust questionnaire that captures patients’ experiences before and after hip or knee replacement surgery. Secondly, to validate this questionnaire and to ascertain how the new questionnaire compares to similar popular measures such as the Oxford Hip and Knee Score and/or EQ5D.

Walk with Path Feasibility and Product Assessment

Walk with Path Feasibility and Product Assessment 

This is an exploratory study to validate and determine the usability of the Path Insight device, a wearable insole that can measure motion and function, in people with osteoarthritis.

Parental Experience of the Paediatric Dysphagia Service

Parental experience of paediatric dysphagia service and analysis of The Swallow Physiology of Infants and Children with Dysphagia

This is a prospective observational study, documenting parental experience of dysphagia in neurotypical children, which will be explored during a focus group part of the study. Dysphagia is a skill-based disorder involving one of the three stages of swallowing.

Bone Imaging Statistical Learning

Bone Imaging Statistical Learning

This study utilises anonymised imaging data from Imperial College NHS Trust to develop AI (artificial intelligence) software to aid in the triage and optimal management of hip and knee osteoarthritis. The goal is to improve patient flow and clinical outcomes for this group of patients. 

Ultrasonic MCL strain monitoring

Ultrasonic MCL strain monitoring

The development and testing of a novel ultrasound tool that would allow clinicians to measure ligament strain (how much a ligament is stretching). This has many potential clinical applications, from improved management of sporting injuries to improving the outcomes of knee replacement surgery. 

ICan Transcranial Magnetic Stimulation (TMS) be used as a novel intra-operative monitor of spinal cord function?

ICan Transcranial Magnetic Stimulation (TMS) be used as a novel intra-operative monitor of spinal cord function?


This is a feasibility/pilot study to study and evaluate the use of Transcranial magnetic stimulation, a non-invasive method, to monitor blood flow to the spinal cord during  complex surgery of the thoracic aorta.

Near Infrared Spectroscopy (NIRS) in vascular disease

Near Infrared Spectroscopy (NIRS) in vascular disease

This is a feasibility/pilot study to evaluate the ability of near infrared spectroscopy to predict and/or diagnose ischaemic spinal cord injury during thoraco-abdominal aortic aneurysm (TAAA) surgery.