Biophotonics and Imaging

Our biophotonics research concerns the application of photonics technologies to the study of disease and the development of diagnostic tools and therapies, leveraging expertise in laser physics, imaging, and spectroscopy. Many of our biophotonics projects utilise fluorescence readouts and span solution-based solution studies of molecular biology, super-resolved microscopy, 2D & 3D single-cell resolved high content analysis (HCA), preclinical imaging and clinical studies involving patients. We also develop and apply advanced mass spectrometry imaging methods, providing complementary biochemical maps of tissues and cells alongside optical measurements.

This is an exciting time for biophotonics as traditional barriers to observation are being pushed back and life scientists can envisage learning about biomolecular processes with unprecedented detail, speed and physiological relevance. We aim to exploit advances in photonics to create new tools and opportunities for molecular cell biology and drug discovery – which today are increasingly enhanced using machine learning.

Our vision is to provide higher-content analysis at all scales of measurement, and to make these tools as widely available as possible by developing low-cost instrumentation with open-source software.

Principal Investigators and Fellowship Holders