Jim Mackey The Fourth Annual NIHR Imperial Patient Safety Translational Research Centre (PSTRC)/Centre for Patient Safety and Service Quality (CPSSQ) Symposium was held on 28th September 2016 at the Royal School of Mines, South Kensington Campus, Imperial College London. It continued the long-standing tradition of engaging researchers, healthcare professionals and members of the public in the latest patient safety research from NIHR Imperial PSTRC, CPSSQ and other organisations.