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Journal articlePeill J, Marguilho M, Erritzoe D, et al., 2024,
Psychedelics and the 'inner healer': Myth or mechanism?
, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 38, Pages: 417-424, ISSN: 0269-8811 -
Journal articleSchlag AK, Nutt DJ, Lynskey M, 2024,
Using real world evidence to optimize care: the case of medical cannabis
, EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH, Vol: 24, Pages: 463-465, ISSN: 1473-7167 -
Journal articleVohryzek J, Cabral J, Timmermann C, et al., 2024,
The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework
, NATIONAL SCIENCE REVIEW, Vol: 11, ISSN: 2095-5138 -
Journal articleThurgur H, Lynskey M, Schlag AK, et al., 2024,
Feasibility of a cannabidiol-dominant cannabis-based medicinal product for the treatment of long COVID symptoms: A single-arm open-label feasibility trial
, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 90, Pages: 1081-1093, ISSN: 0306-5251 -
Journal articleWeiss B, Roseman L, Giribaldi B, et al., 2024,
Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder
, INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION, Vol: 22, Pages: 806-841, ISSN: 1557-1874 -
Journal articleLuppi A, Rosas FE, Noonan MP, et al., 2024,
Oxygen and the spark of human brain evolution: complex interactions of metabolism and cortical expansion across development and evolution
, The Neuroscientist, Vol: 30, Pages: 173-198, ISSN: 1073-8584Scientific theories on the functioning and dysfunction of the human brain require an understanding of its development—before and after birth and through maturation to adulthood—and its evolution. Here we bring together several accounts of human brain evolution by focusing on the central role of oxygen and brain metabolism. We argue that evolutionary expansion of human transmodal association cortices exceeded the capacity of oxygen delivery by the vascular system, which led these brain tissues to rely on nonoxidative glycolysis for additional energy supply. We draw a link between the resulting lower oxygen tension and its effect on cytoarchitecture, which we posit as a key driver of genetic developmental programs for the human brain—favoring lower intracortical myelination and the presence of biosynthetic materials for synapse turnover. Across biological and temporal scales, this protracted capacity for neural plasticity sets the conditions for cognitive flexibility and ongoing learning, supporting complex group dynamics and intergenerational learning that in turn enabled improved nutrition to fuel the metabolic costs of further cortical expansion. Our proposed model delineates explicit mechanistic links among metabolism, molecular and cellular brain heterogeneity, and behavior, which may lead toward a clearer understanding of brain development and its disorders.
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Journal articleLynskey MT, Athanasiou-Fragkouli A, Thurgur H, et al., 2024,
Medicinal cannabis for treating post-traumatic stress disorder and comorbid depression: real-world evidence
, BJPSYCH OPEN, Vol: 10, ISSN: 2056-4724 -
Journal articleVohryzek J, Cabral J, Lord L-D, et al., 2024,
Brain dynamics predictive of response to psilocybin for treatment-resistant depression
, BRAIN COMMUNICATIONS, Vol: 6 -
Journal articleMarrocu A, Kettner H, Weiss B, et al., 2024,
Psychiatric risks for worsened mental health after psychedelic use
, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 38, Pages: 225-235, ISSN: 0269-8811 -
Journal articleKusudo K, Tani H, Yonezawa K, et al., 2024,
Development of the Japanese version of the Ego-Dissolution Inventory (EDI).
, Neuropsychopharmacol Rep, Vol: 44, Pages: 292-297AIM: Psychedelics have recently gained attention as potential therapeutic agents for various psychiatric disorders. Previous research has highlighted that a diminished sense of self, commonly termed "ego-dissolution" is a pivotal feature of the psychedelic-induced state. While the Ego-Dissolution Inventory (EDI) is a widely acknowledged instrument for measuring this phenomenon, no Japanese version has been available. This study aimed to develop a Japanese version of the EDI. METHODS: We adhered to the "Guidelines for Best Practices in the Translation and Cultural Modification Process for Patient-Reported Outcomes Instruments: Document from the ISPOR Committee on Translation and Cultural Modification" during our translation approach. Two Japanese psychiatrists independently conducted initial translations, and a consolidated version was achieved via mutual agreement. This version was then back-translated to English and assessed by the original authors for consistency. The repetitive modification process was conducted in continuous dialogues with the original authors until they accepted the concluding back-translated version. RESULTS: The finalized, approved back-translated version of the EDI is presented in the accompanying figure. In addition, the authorized Japanese version of the EDI is included in the Appendix. CONCLUSIONS: In this study, we successfully developed the Japanese version of the EDI. This instrument will assist in assessing ego-dissolution experiences associated with psychedelic-assisted therapy among Japanese speakers. Additional studies are necessary to evaluate the reliability and validity of this newly translated instrument.
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