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@article{Nielsen:2019:10.26434/chemrxiv.8052623.v1,
author = {Nielsen, C and White, AJP and Sale, D and Bures, J and Spivey, A},
doi = {10.26434/chemrxiv.8052623.v1},
journal = {ChemRxiv},
title = {Hydroarylation of Alkenes by protonation/Friedel-Crafts Trapping – HFIP-Mediated Access to Per-Aryl Quaternary Stereocentres},
url = {http://dx.doi.org/10.26434/chemrxiv.8052623.v1},
year = {2019}
}
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TY  - JOUR
AB  - <jats:p><div><p>Upon treatment with a combination of HFIPand a strong Brønsted acid, alkenes behave as Brønsted bases and protonate to givecarbocations which can be trapped by electron rich arenes. The reaction constitutesa Friedel-Crafts (FC) hydroarylation which proceeds with Markovnikovselectivity and is orthogonal to traditional metal catalyzed processes. Theproducts contain polyarylated quaternary carbon atoms which are difficult toobtain <i>via</i> alternative methods. Intermoleculartransfer hydrogenation  andhydrothiolation are also demonstrated. </p></div></jats:p>
AU  - Nielsen,C
AU  - White,AJP
AU  - Sale,D
AU  - Bures,J
AU  - Spivey,A
DO  - 10.26434/chemrxiv.8052623.v1
PY  - 2019///
TI  - Hydroarylation of Alkenes by protonation/Friedel-Crafts Trapping – HFIP-Mediated Access to Per-Aryl Quaternary Stereocentres
T2  - ChemRxiv
UR  - http://dx.doi.org/10.26434/chemrxiv.8052623.v1
ER  -
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