@article{Piletsky:2022:10.3390/polym14214582,
author = {Piletsky, S and Kassem, S and Yesilkaya, H and Gazioglu, O and Habtom, M and Canfarotta, F and Piletska, E and Spivey, A and Aboagye, E and Piletsky, S},
doi = {10.3390/polym14214582},
journal = {Polymers},
pages = {1--15},
title = {Assessing the in vivo biocompatibility of molecularly imprinted polymer nanoparticles},
url = {http://dx.doi.org/10.3390/polym14214582},
volume = {14},
year = {2022}
}

Download

TY  - JOUR
AB  - Molecularly imprinted polymer nanoparticles (nanoMIPs) are high affinity synthetic receptors which show promise as imaging and therapeutic agents. Comprehensive analysis of the in vivo behaviour of nanoMIPs must be performed before they can be considered for clinical applications. This work reports the solid-phase synthesis of nanoMIPs and an investigation of their biodistribution, clearance and cytotoxicity in a rat model following both intravenous and oral administration. These nanoMIPs were found in each harvested tissue type, including brain tissue, implying their ability to cross the blood brain barrier. The nanoMIPs were cleared from the body via both faeces and urine. Furthermore, we describe an immunogenicity study in mice, demonstrating that nanoMIPs specific for a cell surface protein showed moderate adjuvant properties, whilst those imprinted for a scrambled peptide showed no such behaviour. Given their ability to access all tissue types and their relatively low cytotoxicity, these results pave the way for in vivo applications of nanoMIPs.
AU  - Piletsky,S
AU  - Kassem,S
AU  - Yesilkaya,H
AU  - Gazioglu,O
AU  - Habtom,M
AU  - Canfarotta,F
AU  - Piletska,E
AU  - Spivey,A
AU  - Aboagye,E
AU  - Piletsky,S
DO  - 10.3390/polym14214582
EP  - 15
PY  - 2022///
SN  - 2073-4360
SP  - 1
TI  - Assessing the in vivo biocompatibility of molecularly imprinted polymer nanoparticles
T2  - Polymers
UR  - http://dx.doi.org/10.3390/polym14214582
UR  - https://www.mdpi.com/2073-4360/14/21/4582
UR  - http://hdl.handle.net/10044/1/101168
VL  - 14
ER  - 

Download