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Conference paperLong Q, Merrifield R, Xu X, et al., 2003,
Intra-ventricular blood flow simulation with patient specific geometry
, 4th International IEEE EMBS Special Topic Conference on Information Technology Applications in BiomedicineThis study demonstrates a subject specific approach for simulating blood flow within a left ventricle (LV) by a combined analysis of computational fluid dynamics (CFD) and magnetic resonance imaging (MRI). Time dependent LV morphology and wall movements are measured by 3D multi-slice MRI. The information is then used to build numerical meshes for CFD simulation which provides detailed 3D LV velocity and pressure distributions in the LV cavity. Issues related to mesh generation and the prescription of valvular boundary conditions are also discussed. The predicted flow patterns are compared to that of the published MR measurements, demonstrating the effectiveness of the proposed approach.
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Conference paperPapathanasopoulou P, Zhao SZ, Kohler U, et al., 2003,
MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions
, 10th Annual Meeting of the International-Society-for-Magnetic-Resonance-in-Medicine, Publisher: JOHN WILEY & SONS INC, Pages: 153-162, ISSN: 1053-1807- Author Web Link
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- Citations: 126
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Journal articleGlor FP, Long Q, Hughes AD, et al., 2003,
Reproducibility study of magnetic resonance image-based computational fluid dynamics prediction of carotid bifurcation flow
, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 31, Pages: 142-151, ISSN: 0090-6964- Author Web Link
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- Citations: 70
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Conference paperRicard F, Brechtelsbauer C, Lawrence C, et al., 2003,
Application of electrical resistance tomography technology to pharmaceutical processes
, Pages: 701-706Recent developments in the use of non-intrusive, electrical measurements to interrogate mixing processes in batch vessels have triggered a joint GSK/Imperial College project aimed at assessing the applicability of Electrical Resistance Tomography (ERT) to pharmaceutical process development. A jacketed 3.5 L glass reactor was fitted with 64 platinum sensors arranged on 4 planes and linked to an ITS P2000 data acquisition system. Several vessel/stirrer configurations aimed at mimicking typical plant reactor geometries were investigated in connection with typical process scenarios in the pharmaceutical industry. Variations in local and bulk conductivity measurements were monitored, and the data obtained were compared with spectroscopic on-line monitoring information as well as kinetic and computational fluid dynamics modelling results. Very encouraging results were achieved for model and industrial processes. This approach shows promise for on-line control of process mixing performance as well as efficiency evaluation and optimisation of reactor geometries. This allows us to conclude that ERT is a valuable tool for the development of robust manufacturing processes for Active Pharmaceutical Ingredients.
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Journal articleAugst AD, Barratt DC, Hughes AD, et al., 2003,
Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images
, PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 217, Pages: 393-403, ISSN: 0954-4119- Author Web Link
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- Citations: 21
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Conference paperGlor FP, Ariff B, Augst AD, et al., 2003,
3D ultrasound-based CFD for carotid flow prediction: a reproducibility study
, 2nd MIT Conference on Computational Fluid and Solid Mechanics, Publisher: ELSEVIER SCIENCE BV, Pages: 1701-1704- Author Web Link
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- Citations: 1
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Journal articleLee KW, Xu XY, 2002,
Modelling of flow and wall behaviour in a mildly stenosed tube
, MEDICAL ENGINEERING & PHYSICS, Vol: 24, Pages: 575-586, ISSN: 1350-4533- Author Web Link
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- Citations: 79
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Conference paperAriff B, O'Neill A, Xu XY, et al., 2002,
Divergent effects on cardiac and carotid vascular remodelling in hypertensive subjects treated with candesartan cilexitil & atenolol.
, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 582-582, ISSN: 0194-911X -
Conference paperGlor FP, Long Q, Hughes AD, et al., 2002,
MR based CFD cardiovascular modelling: a reproducibility study on carotid blood flow
, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 582-582, ISSN: 0194-911X -
Conference paperAugst AD, Barratt DC, Hughes AD, et al., 2002,
CFD modeling of carotid bifurcation blood flow using 3D ultrasound
, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 571-571, ISSN: 0194-911X -
Journal articleZhao SZ, Ariff B, Long Q, et al., 2002,
Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans
, JOURNAL OF BIOMECHANICS, Vol: 35, Pages: 1367-1377, ISSN: 0021-9290- Author Web Link
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- Citations: 93
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Journal articleAriff B, Stanton A, Barratt D, et al., 2002,
Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics
, JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, Vol: 3, Pages: 116-122, ISSN: 1470-3203- Author Web Link
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- Citations: 8
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Journal articleStarmans-Kool MJ, Stanton AV, Zhao SZ, et al., 2002,
Measurement of hemodynamics in human carotid artery using ultrasound and computational fluid dynamics
, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 92, Pages: 957-961, ISSN: 8750-7587- Author Web Link
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- Citations: 12
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Journal articleKing E, Xu XY, Hughes AD, et al., 2002,
Quantification of the non-planarity of the human carotid bifurcation
, BIORHEOLOGY, Vol: 39, Pages: 419-424, ISSN: 0006-355X- Author Web Link
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- Citations: 5
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Journal articleLong Q, Xu XY, Kohler U, et al., 2002,
Quantitative comparison of CFD predicted and MRI measured velocity fields in a carotid bifurcation phantom
, BIORHEOLOGY, Vol: 39, Pages: 467-474, ISSN: 0006-355X- Author Web Link
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- Citations: 21
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Journal articleKöhler U, Marshall I, Robertson MB, et al., 2001,
MRI measurement of wall shear stress vectors in bifurcation models and comparison with CFD predictions.
, J Magn Reson Imaging, Vol: 14, Pages: 563-573, ISSN: 1053-1807Steady fluid flow was studied in a simple bifurcation model and in a physiologically realistic model of the human carotid bifurcation. Wall shear stress (WSS) vectors were calculated from phase-contrast (PC) magnetic resonance imaging (MRI) measurements of the velocity field. Velocity measurements in the inflow regions were also used as boundary conditions for computational fluid dynamics (CFD) calculations of WSS, which were compared with those derived from MRI alone. In regions of well-behaved flow, MRI and CFD estimates of WSS were in good general agreement. In regions of disturbed flow, for example near the bifurcation, the quality of the MRI measurements was sufficient for reliable calculation of WSS vectors when a sensitive surface coil was used. The combination of MRI and CFD would seem to be a powerful technique for the investigation of flow phenomena.
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Journal articleAugst AD, Barratt DC, Hughes AD, et al., 2001,
CFD model of a human carotid artery bifurcation reconstructed from 3D ultrasound data
, HYPERTENSION, Vol: 38, Pages: 977-977, ISSN: 0194-911X -
Journal articleLong Q, Xu XY, Ramnarine KV, et al., 2001,
Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis
, JOURNAL OF BIOMECHANICS, Vol: 34, Pages: 1229-1242, ISSN: 0021-9290- Author Web Link
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- Citations: 140
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Journal articleZhao SZ, Zambanini A, Long Q, et al., 2000,
Difference in anatomical features of the femoral artery between male and female
, HYPERTENSION, Vol: 36, Pages: 666-666, ISSN: 0194-911X -
Journal articleXu XY, Zhao SZ, Ariff B, et al., 2000,
Shear stress and mechanical forces in the walls of carotid arteries
, HYPERTENSION, Vol: 36, Pages: 664-664, ISSN: 0194-911X
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