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Conference paperTan FPP, Torii R, Borghi A, et al., 2009,
Analysis of flow patterns in a patient-specific thoracic aortic aneurysm model
, Publisher: Elsevier, Pages: 680-690In this study, a newly developed two-equation transitional model was employed for the prediction of blood flow patterns in a thoracic aortic aneurysm (TAA) where the growth and progression are closely linked to low and oscillating wall shear stresses. Laminar–turbulent transition in the dilated vessel can alter the flow structure, shear stress and pressure distribution within the aneurysm. A patient-specific TAA model was reconstructed from magnetic-resonance (MR) images and measured velocity waveform was used as the inflow condition. Laminar flow and a correlation-based transitional version of Menter’s hybrid k /k x Shear Stress Transport (SST Tran) model were implemented in pulsatile simulations from which WSS distribution was obtained throughout a cardiac cycle and velocity profiles were compared with MR measurements. The correlation-based transitional model was found to produce results in closer agreement with the MR data than the laminar flow simulation.
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Journal articleTan FPP, Soloperto G, Bashford S, et al., 2008,
Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models
, Journal of Biomechanical Engineering, Vol: 130, Pages: 061008-1-061-008-12In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter's hybrid k-/k- shear stress transport (SST) model and its “scale adaptive simulation” (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.
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Journal articleSu J, Gu Z, Li Y, et al., 2008,
An Adaptive Direct Quadrature Method of Moment for Population Balance Equations
, AICHE JOURNAL, Vol: 54, Pages: 2872-2887, ISSN: 0001-1541- Author Web Link
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- Citations: 21
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Conference paperTorii R, Wood NB, Hadjiloizou N, et al., 2008,
Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention
, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 762-762, ISSN: 0194-911X -
Conference paperTorii R, Wood NB, Hadjiloizou N, et al., 2008,
Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention
, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A1-A2, ISSN: 1355-6037- Author Web Link
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- Citations: 2
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Journal articleDownie SP, Raynor SM, Firmin DN, et al., 2008,
Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf
, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 294, Pages: H2112-H2120, ISSN: 0363-6135- Author Web Link
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- Citations: 34
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Journal articleLong Q, Merrifield R, Xu XY, et al., 2008,
Subject-specific computational simulation of left ventricular flow based on magnetic resonance imaging
, PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 222, Pages: 475-485, ISSN: 0954-4119- Author Web Link
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- Citations: 42
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Journal articleBorghi A, Wood NB, Mohiaddin RH, et al., 2008,
Fluid-solid interaction simulation of flow and stress pattern in thoracoabdominal aneurysms: A patient-specific study
, JOURNAL OF FLUIDS AND STRUCTURES, Vol: 24, Pages: 270-280, ISSN: 0889-9746- Author Web Link
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- Citations: 57
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Conference paperTan E, Lee S, Torii R, et al., 2008,
3d modelling of pelvic floor pressures using MRI for evaluating prolapse and obstructed defecation versus asymptomatic controls
, 38th Annual Meeting of the International-Continence-Society, Publisher: WILEY-BLACKWELL, Pages: 614-615, ISSN: 0733-2467 -
Journal articleTan FPP, Soloperto G, Wood NB, et al., 2008,
Advanced computational models for disturbed and turbulent flow in stenosed human carotid artery bifurcation
, IFMBE Proceedings, Vol: 21 IFMBE, Pages: 390-394, ISSN: 1680-0737In this study, newly developed two-equation transitional and turbulence models are employed for the prediction of blood flow patterns in diseased carotid artery where the growth, progression and structure of plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, laminar-turbulent transition in the post-stenotic zone can alter the separation zone length, wall shear stress and pressure distribution over the plaque, with potential implications for stresses within the plaque. A separate validation study was carried out with well established experimental measurements and numerical studies. Laminar flow, Menter's hybrid k-ε/k-ω Shear Stress Transport model and its transitional version were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress and turbulence intensity were conducted. It was found that the transitional version of SST gave better overall agreement with experimental data for pulsatile flow in an axisymmetric stenosed tube and this is further highlighted in the patient-specific geometry simulation results. A magnetic-resonance (MR) image based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using patient-specific boundary conditions. The laminar flow assumption was found to be inadequate when the differences occurred in the wall shear stress analysis of the patient-derived model. © 2008 Springer-Verlag.
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Conference paperTan FPP, Soloperto G, Wood NB, et al., 2008,
Advanced Computational Models for Disturbed and Turbulent Flow in Stenosed Human Carotid Artery Bifurcation
, 4th Kuala Lumpur International Conference on Biomedical Engineering, Publisher: SPRINGER, Pages: 390-+, ISSN: 1680-0737- Author Web Link
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- Citations: 4
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Conference paperLiu D, Wood NB, Xu XY, et al., 2008,
3D reconstruction of the retinal arterial tree based on fundus images using a self-calibration approach
, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: TAYLOR & FRANCIS LTD, Pages: 307-+ -
Journal articleSu J, Gu Z, Li Y, et al., 2007,
Solution of population balance equation using quadrature method of moments with an adjustable factor
, CHEMICAL ENGINEERING SCIENCE, Vol: 62, Pages: 5897-5911, ISSN: 0009-2509- Author Web Link
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- Citations: 39
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Journal articleSun N, Wood NB, Hughes AD, et al., 2007,
Influence of pulsatile flow on LDL transport in the arterial wall
, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 35, Pages: 1782-1790, ISSN: 0090-6964- Author Web Link
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- Citations: 29
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Journal articleAugst AD, Ariff B, Thom SAGM, et al., 2007,
Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery
, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 293, Pages: H1031-H1037, ISSN: 0363-6135- Author Web Link
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- Citations: 66
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Journal articleMa CYJ, Kumar R, Xu XY, et al., 2007,
A combined fluid dynamics, mass transport and cell growth model for a three-dimensional perfused biorector for tissue engineering of haematopoietic cells
, BIOCHEMICAL ENGINEERING JOURNAL, Vol: 35, Pages: 1-11, ISSN: 1369-703X- Author Web Link
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- Citations: 33
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Journal articleDownie SP, Firmin DN, Wood NB, et al., 2007,
Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg
, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 26, Pages: 80-85, ISSN: 1053-1807- Author Web Link
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- Citations: 19
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Journal articleSun N, Wood NB, Hughes AD, et al., 2007,
Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model
, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 292, Pages: H3148-H3157, ISSN: 0363-6135- Author Web Link
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- Citations: 50
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Conference paperTorii R, Wood NB, Hadjiloizou N, et al., 2007,
Does the difference in realistic waveform before and after stenting affect hemodynamics in stenosed coronary artery?
, ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 467-468 -
Conference paperBorghi A, Wood NB, Mohiaddin RH, et al., 2007,
Fluid-solid interaction simulation of flow and stress pattern in thoracoabdominal aneurysms: A patient specific study
, 6th Symposium on Fluid-Structure Interactions, Aeroelasticity and Flow-Induced Vibration and Noise, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 671-675
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