@article{George:2022:10.1126/scitranslmed.abo5795,
author = {George, PM and Reed, A and Desai, SR and Devaraj, A and Faiez, TS and Laverty, S and Kanwal, A and Esneau, C and Liu, MKC and Kamal, F and Man, WD-C and Kaul, S and Singh, S and Lamb, G and Faizi, FK and Schuliga, M and Read, J and Burgoyne, T and Pinto, AL and Micallef, J and Bauwens, E and Candiracci, J and Bougoussa, M and Herzog, M and Raman, L and Ahmetaj-Shala, B and Turville, S and Aggarwal, A and Farne, HA and Dalla, Pria A and Aswani, AD and Patella, F and Borek, WE and Mitchell, JA and Bartlett, NW and Dokal, A and Xu, X-N and Kelleher, P and Shah, A and Singanayagam, A},
doi = {10.1126/scitranslmed.abo5795},
journal = {Science Translational Medicine},
pages = {1--16},
title = {A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae.},
url = {http://dx.doi.org/10.1126/scitranslmed.abo5795},
volume = {14},
year = {2022}
}

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TY  - JOUR
AB  - Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.
AU  - George,PM
AU  - Reed,A
AU  - Desai,SR
AU  - Devaraj,A
AU  - Faiez,TS
AU  - Laverty,S
AU  - Kanwal,A
AU  - Esneau,C
AU  - Liu,MKC
AU  - Kamal,F
AU  - Man,WD-C
AU  - Kaul,S
AU  - Singh,S
AU  - Lamb,G
AU  - Faizi,FK
AU  - Schuliga,M
AU  - Read,J
AU  - Burgoyne,T
AU  - Pinto,AL
AU  - Micallef,J
AU  - Bauwens,E
AU  - Candiracci,J
AU  - Bougoussa,M
AU  - Herzog,M
AU  - Raman,L
AU  - Ahmetaj-Shala,B
AU  - Turville,S
AU  - Aggarwal,A
AU  - Farne,HA
AU  - Dalla,Pria A
AU  - Aswani,AD
AU  - Patella,F
AU  - Borek,WE
AU  - Mitchell,JA
AU  - Bartlett,NW
AU  - Dokal,A
AU  - Xu,X-N
AU  - Kelleher,P
AU  - Shah,A
AU  - Singanayagam,A
DO  - 10.1126/scitranslmed.abo5795
EP  - 16
PY  - 2022///
SN  - 1946-6234
SP  - 1
TI  - A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae.
T2  - Science Translational Medicine
UR  - http://dx.doi.org/10.1126/scitranslmed.abo5795
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36383686
UR  - https://www.science.org/doi/10.1126/scitranslmed.abo5795
UR  - http://hdl.handle.net/10044/1/100974
VL  - 14
ER  - 

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