Project Title: Investigating the role of inducible proteasome subunits in neuronal models of tauopathies
Supervisors: Dr Yu Ye, Dr Johanna Jackson, Professor Amin Hajitou
Location: Level 7, Sir Michael Uren Hub, White City Campus, 86 Wood Lane, W12 0BZ

About Me

I am a PhD student in the Ye lab in the Department of Brain Sciences at Imperial College London, investigating the role of specific proteasomal degradation systems in the pathogenesis of tauopathies, like Alzheimer’s disease. In 2022, I graduated with a BSc in Biochemistry from Imperial, where I became interested in the molecular basis of neurodegenerative disease. As part of my degree, I spent a Year Abroad in the Jockers lab at the Institut Cochin (Paris), where I was able to investigate the importance of tau to metabolic receptor dysfunction in Alzheimer’s disease, alongside a parallel COVID19-focused project. In 2021, I undertook a summer UROP placement in the Ye lab, and was subsequently awarded a President’s scholarship to undertake my PhD at Imperial.


  • 2018–2022: BSc Biochemistry with French for Science, Imperial College London

Research Interests

Aggregate accumulation and pro-inflammatory signalling are key hallmarks of neurodegenerative disorders. Both can be regulated by proteasomes, large multi-subunit complexes responsible for degrading unnecessary or misfolded proteins to maintain protein homeostasis. I am interested in whether immune-activated subunits of the proteasome may be protective or detrimental to progression of neurodegenerative disorders. My project will investigate how these subunits contribute to aggregate accumulation and pro-inflammatory signalling in tauopathies, like Alzheimer’s disease. To achieve this, I am using using super resolution imaging and biochemical techniques on cellular neuronal models, generated from patient-derived induced pluripotent stem cells, in combination with post-mortem brain tissue.

Selected Publications

Cecon E., Burridge M., Cao L., Carter L., Ravichandran R., Dam J., Jockers R. SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET. Cell Chem Biol. 2022; 29(1):74-83. doi: 10.1016/j.chembiol.2021.06.008. PMID: 34246414


EMBL Advanced Fluorescence Imaging Techniques Course (Boehringer Ingelheim Grant)

Professional memberships

  • Biochemical Society
  • Quantitative Biological Imaging Society


  • Great Exhibition Road Festival
  • Making It Brain volunteer

Contact Details

LinkedIn: matilda-burridge-a518b41b4