DNA

All major neurodegenerative diseases are characterised by substantial heritability and large-scale genetic efforts have identified variants associated with disease. These often lie in non-coding, regulatory regions and cannot be linked to any functional outcomes. Our research combines methods from statistical genetics with in-depth transcriptional and epigenetic profiling of individual cell types in the brain, to discover und interpret functional outcomes of genetic and environmental risk factors of neurodegenerative diseases.

Objectives and contact

Key objectives

  • Identify cell types and brain regions in which genetic risk variants cause the onset of neurodegenerative disease
  • Understand epigenetic and transcriptional consequences of genetic and environmental risk factors for neurodegenerative disease
  • Link genetic risk variants to regulatory and functional outcomes
  • Investigate selective vulnerability of cell populations to genetic risk factors
  • Characterize and understand altered epigenetic regulation in neurodegenerative disease

If you have any enquiries about this theme or are interested in joining one of the groups, please contact the programme leaders:

Dr Sarah Marzi
s.marzi@imperial.ac.uk
Edmond and Lily Safra Research Fellow 
View Dr Marzi's professional webpage here
UK DRI Neurogenomics Lab website 

Dr Raffaella Nativio
r.nativio@imperial.ac.uk
Lecturer in Dementia Research, Department of Brain Sciences
UK DRI Fellow

Dr Alexi Nott
a.nott@imperial.ac.uk
UK DRI Fellow
View Dr Nott's laboratory website here

Dr Nathan Skene
n.skene@imperial.ac.uk
Lecturer in Dementia Research, Department of Brain Sciences
UK DRI Fellow
View Dr Skene's professional webpage here
UK DRI Neurogenomics Lab website 

We are keen to recruit enthusiastic scientists to lead novel and exciting projects!