Citation

BibTex format

@article{Anwar:2026,
author = {Anwar, M and Sarkar, M and Ford, K and Angelini, GD and Punjabi, PP and Guan, Y and Laftah, A and Chamorro-Jorganes, A and Ji, J and Srivastava, PK and Petretto, E and Emanueli, C},
journal = {JACC: Basic to Translational Science},
title = {Human left ventricle circRNA-miRNA-mRNA network analyses reveal a novel proangiogenic role for circNPHP1 under ischemic conditions},
volume = {11},
year = {2026}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Therapies promoting microvascular flow and endothelial repair require effective identification of new targets in ischemic heart disease (IHD). The aim of this study was to unravel and functionally investigate circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) networks in endothelial cells in the context of IHD and Type 2 Diabetes Mellitus (T2DM). We performed RNA sequencing on left ventricle biopsies from patients with IHD, IHD and T2DM and non-IHD. Next, we created circRNA-miRNA-mRNA networks and mechanistically investigated the top circRNA-miRNA sponging interactions in endothelial cells (ECs). We found that circNPHP1 promotes angiogenesis via sponging of miR-221-3p and regulates its downstream target genes, VEGFA and BCL2 in IHD and T2DM.
AU  - Anwar,M
AU  - Sarkar,M
AU  - Ford,K
AU  - Angelini,GD
AU  - Punjabi,PP
AU  - Guan,Y
AU  - Laftah,A
AU  - Chamorro-Jorganes,A
AU  - Ji,J
AU  - Srivastava,PK
AU  - Petretto,E
AU  - Emanueli,C
PY  - 2026///
SN  - 2452-302X
TI  - Human left ventricle circRNA-miRNA-mRNA network analyses reveal a novel proangiogenic role for circNPHP1 under ischemic conditions
T2  - JACC: Basic to Translational Science
VL  - 11
ER  -
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