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@article{Wu:2026:10.1016/j.chest.2026.03.016,
author = {Wu, Z and Moor, K and Wijsenbeek, MS and Schlecker, C and Weimann, G and Maher, TM and Molyneaux, PL},
doi = {10.1016/j.chest.2026.03.016},
journal = {Chest},
pages = {467--476},
title = {The Impact of Disease Severity and Symptoms on Anxiety and Depression in Individuals With Idiopathic Pulmonary Fibrosis.},
url = {http://dx.doi.org/10.1016/j.chest.2026.03.016},
volume = {170},
year = {2026}
}
TY - JOUR
AB - BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a debilitating, life-limiting fibrotic lung disease. Symptoms including breathlessness, cough, and fatigue, together with disease severity, contribute to psychological burden, yet their relationship with anxiety and depression remains unclear. RESEARCH QUESTION: In patients with IPF, what is the prevalence and severity of anxiety and depression, and what are their associations with symptoms and disease severity? STUDY DESIGN AND METHODS: This observational study prospectively recruited patients with incident IPF. Hospital Anxiety and Depression Scale (HADS), Dyspnea-12, Leicester Cough Questionnaires, cough visual analog scales, Living with IPF (L-IPF), and lung function were assessed at baseline and 12 months. RESULTS: Two hundred sixty-nine patients with IPF (mean age, 73.5 years; 81% male) were recruited; 157 completed follow-up. Mean FVC % predicted ± SD was 79% ± 14.7%. At baseline, the prevalence of anxiety and depression (HADS score ≥ 8) was 27.5% and 28.3%, respectively (suggestive HADS 8-10: 18.6% and 14.9%; probable HADS ≥ 11: 8.9% and 13.3%, respectively). On multivariable analysis, worse Dyspnea-12 and poorer L-IPF energy were independent factors for both anxiety and depression at baseline; younger age was a factor for anxiety. Baseline lung function did not correlate with HADS anxiety or HADS depression. At follow-up, HADS anxiety scores increased numerically, below reported minimal clinically important difference values, with no change in HADS depression scores. Younger age, higher Dyspnea-12 scores, and poorer L-IPF energy were associated with greater increases in anxiety. Moderate or weak correlations were observed between changes in HADS and longitudinal changes in patient-reported outcomes (worsening breathlessness, cough, and energy levels). Changes in FVC % predicted did not correlate with HADS. INTERPRETATION: Our results show that anxiety and depression are common in patient
AU - Wu,Z
AU - Moor,K
AU - Wijsenbeek,MS
AU - Schlecker,C
AU - Weimann,G
AU - Maher,TM
AU - Molyneaux,PL
DO - 10.1016/j.chest.2026.03.016
EP - 476
PY - 2026///
SP - 467
TI - The Impact of Disease Severity and Symptoms on Anxiety and Depression in Individuals With Idiopathic Pulmonary Fibrosis.
T2 - Chest
UR - http://dx.doi.org/10.1016/j.chest.2026.03.016
UR - https://www.ncbi.nlm.nih.gov/pubmed/41921906
VL - 170
ER -