In this section
@article{Massen:2026,
author = {Massen, G and Jenkins, G and Stewart, I and Navaratnam, V and Quint, J},
journal = {BMJ Open},
title = {Temporal trends in single and multiple organ fibrosis prevalence and primary care consultations: a population based cohort study of 5·8 million individuals in England},
year = {2026}
}
TY - JOUR
AB - ObjectiveTo understand how prevalence estimates of single and multiple organ fibrosis have changed from 2012 to 2022.DesignRetrospective population-based cohort studySettingData from primary (Clinical Practice Resource Datalink Aurum) and secondary care (Hospital Episode Statistics Admitted Patient Care) electronic health records were used to conduct this study.ParticipantsAdults age 18 years and over whose primary and secondary care records were available for research.Main outcome measureFibrotic conditions previously determined from a Delphi survey of clinicians; diagnoses were found in either primary or secondary care records. The primary analysis estimated the prevalence of both single and multiple organ fibrosis prevalence. A secondary analysis used Cox proportional hazards models to investigate the association between the time-updated number of fibrotic conditions and risk of death adjusting for age and sex.ResultsThe cohort consisted of 5,839,459 people with at least one fibrotic condition and a denominator of 18,784,962 people. Over the study period prevalence of fibrotic conditions increased by 6.72%, as of 2022, 19·95% (95%CI:19·92 to 19·98) of adults had at least one fibrotic condition. Prevalence of multiple organ fibrosis increased from 4·78% (95%CI:4·76 to 4·79) in 2012 to 8·51% (95%CI:8·50 to 8·53) in 2022. In the year preceding diagnosis of single organ fibrosis, the median number of primary care consultations was 14 compared with 21 consultations for people with multiple organ fibrosis. Compared with people with single organ fibrosis, people with two fibrotic conditions had a mortality hazard ratio of 2.90 (95%CI: 2.87-2.93), whilst people with three fibrotic conditions had a mortality hazard ratio of 5.22 (95% CI:5.14-5.30).ConclusionsPrevalence of single and multiple organ fibrosis has substantially increased over a decade. People with multiple organ fibrosis access healthcare more tha
AU - Massen,G
AU - Jenkins,G
AU - Stewart,I
AU - Navaratnam,V
AU - Quint,J
PY - 2026///
SN - 2044-6055
TI - Temporal trends in single and multiple organ fibrosis prevalence and primary care consultations: a population based cohort study of 5·8 million individuals in England
T2 - BMJ Open
ER -