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BibTex format

@article{Hasegawa:2026:10.1183/23120541.00602-2026,
author = {Hasegawa, T and Yang, F and Kermani, N and Lunding, H and Zhao, F and Chadeau, M and Adcock, IM and Kim, T-B and Bhavsar, P and Chung, KF},
doi = {10.1183/23120541.00602-2026},
journal = {ERJ Open Research},
pages = {00602--2026},
title = {Sputum eosinophil and neutrophil activation biomarkers in severe asthma},
url = {http://dx.doi.org/10.1183/23120541.00602-2026},
year = {2026}
}
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TY  - JOUR
AB  - <jats:sec>                    <jats:title>Background</jats:title>                    <jats:p>Asthma is characterized by different inflammatory phenotypes. We hypothesized that sputum eosinophil-derived neurotoxin (EDN), and myeloperoxidase (MPO) or interleukin-8 (IL-8) levels improves the granulocytic characterization of asthma compared to sputum granulocyte counts.</jats:p>                  </jats:sec>                  <jats:sec>                    <jats:title>Methods</jats:title>                    <jats:p>EDN, IL-8 and MPO were assayed in induced sputum supernatants from patients with severe and mild-to-moderate asthma, and healthy controls. Elevated cut-off values were determined using Youden Index. Asthma patients were stratified in four subgroups based on EDN and IL8 or MPO levels.</jats:p>                  </jats:sec>                  <jats:sec>                    <jats:title>Results</jats:title>                    <jats:p>                      Sputum EDN, IL-8 and MPO levels were higher in severe asthma (n=193) than in controls (n=40). Optimal cut-offs were 103.5ng·mL                      <jats:sup>−1</jats:sup>                      for EDN, 1150.7pg·mL                      <jats:sup>−1</jats:sup>                      for IL-8 and 220ng·mL                      <jats:sup>−1</jats:sup>                      for MPO. 53 patients (23%) were EDN                      <jats:sup>High</jats:sup>                      IL-8                      <jats:sup>Low</jats:sup>                      , 16 (7%) EDN                      <jats:sup>Low</jats:sup>                      IL-8                      <jats:sup>High</jats:sup>                      , 112 (49%) EDN                      <jats:sup>High</jats:sup>                      IL-8
AU  - Hasegawa,T
AU  - Yang,F
AU  - Kermani,N
AU  - Lunding,H
AU  - Zhao,F
AU  - Chadeau,M
AU  - Adcock,IM
AU  - Kim,T-B
AU  - Bhavsar,P
AU  - Chung,KF
DO  - 10.1183/23120541.00602-2026
EP  - 2026
PY  - 2026///
SP  - 00602
TI  - Sputum eosinophil and neutrophil activation biomarkers in severe asthma
T2  - ERJ Open Research
UR  - http://dx.doi.org/10.1183/23120541.00602-2026
UR  - https://doi.org/10.1183/23120541.00602-2026
ER  -
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