In this section
@article{Macanovic:2025:10.1016/j.jaccas.2025.103795,
author = {Macanovic, P and Cheng, K and Ramasamy, A and Baksi, J and De, Silva P},
doi = {10.1016/j.jaccas.2025.103795},
journal = {JACC: Case Reports},
title = {Persistent angina with non-obstructive coronary artery disease: unmasking coronary microvascular dysfunction post-oncotherapy},
url = {http://dx.doi.org/10.1016/j.jaccas.2025.103795},
volume = {30},
year = {2025}
}
TY - JOUR
AB - BackgroundCoronary microvascular dysfunction (CMD) is frequently the cause of patients presenting with angina and non-obstructed coronary arteries (ANOCA) and may have increased prevalence in cancer survivors. Case SummaryWe report a case of refractory angina in a survivor of Hodgkin lymphoma, previously treated with radiotherapy and chemotherapy. After demonstrating unobstructed epicardial arteries, advanced diagnostics including quantitative stress perfusion cardiac MRI and invasive coronary physiology testing, revealed CMD as a likely sequela of oncotherapy and informed initiation of mechanism-specific treatment. DiscussionCMD may represent an under-recognized cardiotoxicity of oncotherapy. This case highlights the value of formal, multimodal coronary microvascular function assessment to identify CMD and implement stratified management. Future systematic evaluation investigating the relationship and underlying mechanisms of oncotherapy in CMD is warranted.Take Home messagesIn cancer survivors presenting with ANOCA, clinicians should have a high index of suspicion for CMD and consider systematic evaluation to guide stratified treatment.
AU - Macanovic,P
AU - Cheng,K
AU - Ramasamy,A
AU - Baksi,J
AU - De,Silva P
DO - 10.1016/j.jaccas.2025.103795
PY - 2025///
SN - 2666-0849
TI - Persistent angina with non-obstructive coronary artery disease: unmasking coronary microvascular dysfunction post-oncotherapy
T2 - JACC: Case Reports
UR - http://dx.doi.org/10.1016/j.jaccas.2025.103795
UR - https://www.jacc.org/doi/abs/10.1016/j.jaccas.2025.103795
VL - 30
ER -