BibTex format
@article{Hajhosseiny:2025:10.1016/j.jocmr.2025.101898,
author = {Hajhosseiny, R and Hartley, A and Cole, G and Munoz, C and Sethi, A and Al-Lamee, R and Khawaja, S and Zaman, S and Howard, J and Gopalan, D and Ben, Ariff and Kaprielian, R and Neji, R and Kunze, KP and Kaura, A and Prieto, C and Khamis, R and Botnar, RM},
doi = {10.1016/j.jocmr.2025.101898},
journal = {Journal of Cardiovascular Magnetic Resonance},
title = {Free-breathing, non-contrast, 3D whole-heart coronary MRI for the identification of culprit and vulnerable atherosclerotic plaque},
url = {http://dx.doi.org/10.1016/j.jocmr.2025.101898},
volume = {27},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundDetection of vulnerable coronary plaque can predict future myocardial infarctions. We have developed a novel, non-contrast cardiovascular magnetic resonance sequence (iT2prep-BOOST), enabling simultaneous, co-registered coronary angiography and plaque detection.ObjectivesTo validate iT2prep-BOOST in patients with non-ST-segment elevation myocardial infarction (NSTEMI).Methods41 patients with suspected NSTEMI were recruited. Invasive coronary angiography ± intravascular imaging was used to classify coronary segments into the following categories: normal, non-culprit and culprit segments; stenosed segments as well as segments with vulnerable plaque features (lipid, calcium, fibroatheroma, thin cap fibroatheroma (TCFA), plaque-rupture and thrombus). The plaque/myocardial signal intensity ratio (PMR) in each coronary segment was analyzed on iT2prep-BOOST.ResultsThe mean ± standard deviation PMR of culprit segments was significantly higher than non-culprit segments and normal segments (1.01 ± 0.14 vs. 0.67 ± 0.18 vs. 0.35 ± 0.24, P<0.001 respectively). Coronary segments with lipid, calcium and fibroatheroma had a significantly higher PMR compared to normal coronary segments (P<0.001), but significantly lower than segments with plaque-rupture and intraluminal thrombus (P<0.05). There was a progressive increase in PMR with increasing coronary segment stenosis (P<0.001). There was a significant association on multivariable analysis between HbA1c as well as family history of coronary artery disease and mean PMR (P=0.05 and P=0.04 respectively).ConclusionsiT2prep-BOOST has the potential to simultaneously visualize coronary artery lumen and plaque and differentiate normal segments from non-culprit and culprit plaque segments non-invasively and without contrast. The prognostic value of PMR needs to be investigated in a prospective multicenter study.
AU - Hajhosseiny,R
AU - Hartley,A
AU - Cole,G
AU - Munoz,C
AU - Sethi,A
AU - Al-Lamee,R
AU - Khawaja,S
AU - Zaman,S
AU - Howard,J
AU - Gopalan,D
AU - Ben,Ariff
AU - Kaprielian,R
AU - Neji,R
AU - Kunze,KP
AU - Kaura,A
AU - Prieto,C
AU - Khamis,R
AU - Botnar,RM
DO - 10.1016/j.jocmr.2025.101898
PY - 2025///
SN - 1097-6647
TI - Free-breathing, non-contrast, 3D whole-heart coronary MRI for the identification of culprit and vulnerable atherosclerotic plaque
T2 - Journal of Cardiovascular Magnetic Resonance
UR - http://dx.doi.org/10.1016/j.jocmr.2025.101898
UR - https://doi.org/10.1016/j.jocmr.2025.101898
VL - 27
ER -