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@article{Pisacano:2026:jleuko/qiaf142,
author = {Pisacano, N and Evans, RA and Nutley, AS and Lodge, KM and Prendecki, M},
doi = {jleuko/qiaf142},
journal = {Journal of Leukocyte Biology},
title = {Actin regulation of neutrophil effector mechanisms in health and disease},
url = {http://dx.doi.org/10.1093/jleuko/qiaf142},
volume = {118},
year = {2026}
}
TY - JOUR
AB - Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganization of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of neutrophil cytoskeletal properties results in disruption of neutrophil structural integrity, in turn altering their immune response capabilities. We outline how actin and actin polymerization are essential for cell processes, the role of actin in neutrophil function, and how disruption of actin can lead and contribute to a range of disease pathogeneses.
AU - Pisacano,N
AU - Evans,RA
AU - Nutley,AS
AU - Lodge,KM
AU - Prendecki,M
DO - jleuko/qiaf142
PY - 2026///
SN - 0741-5400
TI - Actin regulation of neutrophil effector mechanisms in health and disease
T2 - Journal of Leukocyte Biology
UR - http://dx.doi.org/10.1093/jleuko/qiaf142
UR - https://doi.org/10.1093/jleuko/qiaf142
VL - 118
ER -