Continuous flow reaction platforms

ThalesNano H-Cube Pro and Phoenix Flow Reactor

One H-Cube Pro and one Phoenix high temperature flow reactors (ThalesNano) for:

• Reaction scale-up in flow
• Homogeneous and heterogeneous flow systems
• High temperature (up to 450 °C) and pressurre (up to 200 bar)
• In-line analytics (e.g. ReactIR) for the study of reaction intermediates and hazardous processes
• Automated column changer for up to 6 independently heated catalyst cartridges

Vapourtec R-Series Flow Reactor

An R-Series Vapourtec system for liquid flow reactions comprising:

• Fully acid resistant pump modules
• Two piston pumps
• Two peristaltic pumps feeding capable of delivering slurries and gasses
• 4 reactor positions, independently controllable
• Reaction temperature of -70 to 250 °C
• Microreactors
• UV LED reactor for photochemial reactions
• Autosampler and fraction collector

fReactor

A fReactor, system containing up to 5 small volume continuous stirred tank reactors connected in series.

• 2 mL individual stage volume - up to 10 mL total volume
• Up to 100 psi pressure
• Works on a common stirrer hotplate
• Good chemical compatibility (reactor materials: PEEK and toughened glass; tubings material: PTFE)

Uniqsis FlowSyn and FlowUV

A Uniqsis FlowSyn for liquid flow reactions with:

• 2 high-pressure pump channels with reagent injectors (up to 10 mL/min)
• 1 tubular reaction module (up to 260 °C and 100 bar)
• 1 column heater

A Uniqsis FlowUV for in-line UV-Vis analysis

• Flow cell is transparent PFA reaction tubing
• Dip-probe for batch experiments available
• Can be positioned virtually anywhere in the flow path
• Up to 35 bar at room temperature
• 220-1050nm pulsed Xenon source
• Up to 5 user-selected wavelength real-time monitoring
• Full spectrum mode or multiple fixed wavelength modes

H-Genie Hydrogen Generator

One H-genie high pressure – high flow rate H₂ generator for hydrogenation reactions in flow or in batch.

• Pressure range 1-100 bar
• Flow rate range 0.1-1 L/min
• Hydrogen electrochemically generated from DI water
• High purity hydrogen (99.99% at 100 bar)
• Built-in safety features (hydrogen and water leak detectors, internal pressure test, …)
• Monitors hydrogen uptake and logs exportable data
• Different setting options for flow, batch and balloon

Synple Capsule Chemistry

One Synple platform (on loan) which allows fully automated, capsule-based synthesis. Synthesise and purify chemicals at the click of a button, by only adding the starting materials, the right solvents and the desired cartridge for the target reaction.

Available reaction cartridges include:

• Reductive amination
• N-Etherocycle formation (SnAP)
• PROTAC formation
• Biotin Tags
• Mitsunobu
• Boc protection
• Boc de-protection
• Deoxyfluorination
• Azide formation