portrait of Dr Paulose NadappuramISSF Springboard Fellowship

Single Mitochondrion Sequencing using Nanoscale Tweezers

Development of Nanotweezer platforms for single cell Analysis

Single cell analysis is crucial in elucidating the genetic diversity of tissues and organs to aid the accurate design of disease models and patient-specific therapies. My research at Imperial College is focused on developing new single molecule manipulation platforms for real-time analysis and perturbation of living cells. This platforms can enable the analysis of transcriptional profile and function of individual organelles in cells to facilitate the selection of most appropriate preventative and therapeutic intervention tailored to the needs of individual patients. Furthermore, this method will help to understand disease mechanisms and characterise the effects of drug treatment.


Binoy Paulose Nadappuram is a research associate in the Department of Chemistry, Imperial College London. Binoy obtained his PhD from the University of Warwick, where he developed new electrochemical methods for quantitative visualization ion fluxes at physiochemical (Anal. Chem., 2013 (85) 8070, Anal. Chem., 2015(87) 3566) and biological (Soft Matter, 2014 (10) 8433, J. Am. Chem. Soc., 2016 (9) 3152) interfaces. He also holds a Masters degree (MTech) in Industrial Biotechnology from BIST India. Prior to joining the University of Warwick, Binoy worked as a Research Engineer at the Centre of Innovation in Environment and Water Technology (EWT COI), Singapore.