BibTex format

author = {Saitta, S and Pirola, S and Piatti, F and Votta, E and Lucherini, F and Pluchinotta, F and Carminati, M and Lombardi, M and Geppert, C and Cuomo, F and Figueroa, C and Xu, X and Redaelli, A},
doi = {10.1016/j.jbiomech.2019.07.004},
journal = {Journal of Biomechanics},
pages = {13--21},
title = {Evaluation of 4D Flow MRI-based non-invasive pressure assessment in aortic coarctations},
url = {},
volume = {94},
year = {2019}

RIS format (EndNote, RefMan)

AB - Severity of aortic coarctation (CoA) is currently assessed by estimating trans-coarctation pressure drops through cardiac catheterization or echocardiography. In principle, more detailed information could be obtained non-invasively based on space- and time-resolved magnetic resonance imaging (4D flow) data. Yet the limitations of this imaging technique require testing the accuracy of 4D flow-derived hemodynamic quantities against other methodologies.With the objective of assessing the feasibility and accuracy of this non-invasive method to support the clinical diagnosis of CoA, we developed an algorithm (4DF-FEPPE) to obtain relative pressure distributions from 4D flow data by solving the Poisson pressure equation. 4DF-FEPPE was tested against results from a patient-specific fluid-structure interaction (FSI) simulation, whose patient-specific boundary conditions were prescribed based on 4D flow data. Since numerical simulations provide noise-free pressure fields on fine spatial and temporal scales, our analysis allowed to assess the uncertainties related to 4D flow noise and limited resolution.4DF-FEPPE and FSI results were compared on a series of cross-sections along the aorta. Bland-Altman analysis revealed very good agreement between the two methodologies in terms of instantaneous data at peak systole, end-diastole and time-averaged values: biases (means of differences) were +0.4mmHg, −1.1mmHg and +0.6mmHg, respectively. Limits of agreement (2 SD) were ±0.978mmHg, ±1.06mmHg and ±1.97mmHg, respectively. Peak-to-peak and maximum trans-coarctation pressure drops obtained with 4DF-FEPPE differed from FSI results by 0.75mmHg and −1.34mmHg respectively. The present study considers important validation aspects of non-invasive pressure difference estimation based on 4D flow MRI, showing the potential of this technology to be more broadly applied to the clinical practice.
AU - Saitta,S
AU - Pirola,S
AU - Piatti,F
AU - Votta,E
AU - Lucherini,F
AU - Pluchinotta,F
AU - Carminati,M
AU - Lombardi,M
AU - Geppert,C
AU - Cuomo,F
AU - Figueroa,C
AU - Xu,X
AU - Redaelli,A
DO - 10.1016/j.jbiomech.2019.07.004
EP - 21
PY - 2019///
SN - 0021-9290
SP - 13
TI - Evaluation of 4D Flow MRI-based non-invasive pressure assessment in aortic coarctations
T2 - Journal of Biomechanics
UR -
UR -
UR -
VL - 94
ER -