BibTex format
@article{Dehasque:2020:10.1002/evl3.165,
author = {Dehasque, M and avila-Arcos, MC and Diez-del-Molino, D and Fumagalli, M and Guschanski, K and Lorenzen, ED and Malaspinas, A-S and Marques-Bonet, T and Martin, MD and Murray, GGR and Papadopulos, AST and Therkildsen, NO and Wegmann, D and Dalen, L and Foote, AD},
doi = {10.1002/evl3.165},
journal = {Evolution Letters},
pages = {94--108},
title = {Inference of natural selection from ancient DNA},
url = {http://dx.doi.org/10.1002/evl3.165},
volume = {4},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct quantification of population parameters collected before, during, and after genetic changes driven by selection. In this Comment and Opinion, we advocate for the inclusion of temporal sampling and the generation of paleogenomic datasets in evolutionary biology, and highlight some of the recent advances that have yet to be broadly applied by evolutionary biologists. In doing so, we consider the expected signatures of balancing, purifying, and positive selection in time series data, and detail how this can advance our understanding of the chronology and tempo of genomic change driven by selection. However, we also recognize the limitations of such data, which can suffer from postmortem damage, fragmentation, low coverage, and typically low sample size. We therefore highlight the many assumptions and considerations associated with analyzing paleogenomic data and the assumptions associated with analytical methods.
AU - Dehasque,M
AU - avila-Arcos,MC
AU - Diez-del-Molino,D
AU - Fumagalli,M
AU - Guschanski,K
AU - Lorenzen,ED
AU - Malaspinas,A-S
AU - Marques-Bonet,T
AU - Martin,MD
AU - Murray,GGR
AU - Papadopulos,AST
AU - Therkildsen,NO
AU - Wegmann,D
AU - Dalen,L
AU - Foote,AD
DO - 10.1002/evl3.165
EP - 108
PY - 2020///
SN - 2056-3744
SP - 94
TI - Inference of natural selection from ancient DNA
T2 - Evolution Letters
UR - http://dx.doi.org/10.1002/evl3.165
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000521554600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/evl3.165
VL - 4
ER -