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  • Journal article
    van Thor JJ, Gensch T, Hellingwerf KJ, Johnson LNet al., 2002,

    Phototransformation of green fluorescent protein with UV and visible light leads to decarboxylation of glutamate 222

    , NATURE STRUCTURAL BIOLOGY, Vol: 9, Pages: 37-41, ISSN: 1072-8368
    • Cite
    • Citations: 187
  • Journal article
    Salamin N, Hodkinson TR, Savolainen V, 2002,

    Building supertrees: An empirical assessment using the grass family (Poaceae)

    , SYSTEMATIC BIOLOGY, Vol: 51, Pages: 136-150, ISSN: 1063-5157
    • Cite
    • Citations: 81
  • Journal article
    Mezzasoma L, Bacarese-Hamilton T, Di Cristina M, Rossi R, Bistoni F, Crisanti Aet al., 2002,

    Antigen microarrays for serodiagnosis of infectious diseases

    , CLINICAL CHEMISTRY, Vol: 48, Pages: 121-130, ISSN: 0009-9147
    • Cite
    • Citations: 168
  • Journal article
    Allard STM, Beis K, Giraud MF, Hegeman AD, Gross JW, Wilmouth RC, Whitfield C, Graninger M, Messner P, Allen AG, Maskell DJ, Naismith JHet al., 2002,

    Toward a structural understanding of the dehydratase mechanism

    , STRUCTURE, Vol: 10, Pages: 81-92, ISSN: 0969-2126
    • Cite
    • Citations: 96
  • Journal article
    Nunes-Correia I, Eulalio A, Nir S, Duzgunes N, Ramalho-Santos J, Pedroso de Lima MCet al., 2002,

    Fluorescent probes for monitoring virus fusion kinetics: comparative evaluation of reliability

    , Biochim Biophys Acta, Vol: 1561, Pages: 65-75, ISSN: 0006-3002

    Fluorescence assays for viral membrane fusion employ lipidic probes whose kinetics of fluorescence dequenching should mimic the actual kinetics of membrane merging. We examined the fusion of influenza virus with CEM cells, erythrocyte ghosts or liposomes by monitoring the fluorescence dequenching of each one of the three probes, octadecylrhodamine B chloride (R18), N-(lissamine rhodamine B sulfonyl)phosphatidylethanolamine (Rh-PE), or rac-2,3-dioleoylglycerol ester of rhodamine B (DORh-B), inserted into the virus membrane. Experimental conditions were designed to allow a clear distinction between membrane mixing and non-specific probe transfer. Fluorescence dequenching observed with Rh-PE was much slower than with R18, unless a particular experimental procedure was used. Using liposomes as a target membrane, the kinetics and extent of the decrease in resonance energy transfer between N-(7-nitro-2,1,3-benzoxadiazol-4-yl)phosphatidylethanolamine (NBD-PE) and Rh-PE, initially embedded in the liposome membrane, were matched by that of the dequenching of viral R18, but not of viral Rh-PE. DORh-B was found not to be appropriate to follow membrane merging. Our results indicate that on a time scale of several minutes R18 more accurately reflects the kinetics of membrane fusion. Nevertheless, control experiments should be performed to evaluate non-specific probe transfer of R18 molecules, whose contribution to fluorescence dequenching can become significant after long incubation times.
  • Journal article
    Davis DM, Carlin LM, Eleme K, French PMW, McCann F, Phillips D, Siegel J, Suhling K, Taner S, Vanherberghen B, Webb S, Yanagi Ket al., 2002,

    Imaging the construction of immunological synapses

    , TISSUE ANTIGENS, Vol: 59, Pages: 3-4, ISSN: 0001-2815
  • Conference paper
    Kvansakul M, Bogin O, Rom E, Singer J, Yayon A, Hohenester Eet al., 2002,

    STRUCTURAL STUDIES OF COLLAGEN X AND COLLAGEN VIII NC1 DOMAINS

    , Publisher: INT UNION CRYSTALLOGRAPHY, Pages: C297-C297, ISSN: 2053-2733
  • Conference paper
    Sternberg MJE, Alves R, Chaleil R, Kelley LA, Islam SA, MacCallum RM, Muller Aet al., 2002,

    EXPLOITING PROTEIN STRUCTURE IN THE POST GENOME ERA

    , Publisher: INT UNION CRYSTALLOGRAPHY, Pages: C4-C4, ISSN: 2053-2733
  • Conference paper
    Jormakka M, Toernroth S, Byrne B, Iwata Set al., 2002,

    STRUCTURAL STUDIES ON FORMATE DEHYDROGENASE-N FROM <i>E</i>. <i>COLI</i>

    , Publisher: INT UNION CRYSTALLOGRAPHY, Pages: C207-C207, ISSN: 2053-2733
  • Book
    Telford JL, Pizza M, Grandi G, Rappuoli Ret al., 2002,

    Reverse vaccinology: from genome to vaccine

    , Publisher: ACADEMIC PRESS INC
  • Journal article
    Ekstrom JMM, Dones JPG, Willis J, Tobias J, Dutson G, Barré Net al., 2002,

    New information on the distribution, status and conservation of terrestrial bird species in Grande Terre, New Caledonia

    , EMU-AUSTRAL ORNITHOLOGY, Vol: 102, Pages: 197-207, ISSN: 0158-4197
    • Cite
    • Citations: 16
  • Journal article
    Ewers RM, 2002,

    The influence of honeydew on arthropod community composition in a New Zealand beech forest

    , New Zealand Journal of Ecology, Pages: 23-29
  • Journal article
    Ewers RM, Didham RK, Ranson LH, 2002,

    The Hope River forest fragmentation project

    , The Weta: Bulletin of the Entomological Society of New Zealand, Vol: 24, Pages: 25-34
  • Conference paper
    Peace C, Vithanage V, Turnbull C, Carroll BJet al., 2002,

    Characterising macadamia germplasm with codominant radiolabelled DNA amplification fingerprinting (RAF) markers

    , International Symposium on Tropical and Subtropical Fruits, Publisher: INTERNATIONAL SOCIETY HORTICULTURAL SCIENCE, Pages: 371-380, ISSN: 0567-7572
  • Journal article
    Sutton-Smith M, Morris HR, Grewal PK, Hewitt JE, Bittner RE, Goldin E, Schiffmann R, Dell Aet al., 2002,

    MS screening strategies: investigating the glycomes of knockout and myodystrophic mice and leukodystrophic human brains

    , GLYCOGENOMICS: THE IMPACT OF GENOMICS AND INFORMATICS ON GLYCOBIOLOGY, Vol: 69, Pages: 105-115, ISSN: 0067-8694
    • Cite
    • Citations: 20
  • Journal article
    Knutton S, Shaw R, Frankel G, 2002,

    Interaction of enteropathogenic <i>Escherichia coli</i> with red blood cell monolayers

    , BACTERIAL PATHOGENESIS, PT C, Vol: 358, Pages: 350-355, ISSN: 0076-6879
  • Book chapter
    Vogler AP, Purvis A, 2002,

    Comparative method and evolution

    , Molecular Systematics and Evolution, Editors: De, Giribet, Wheeler, Basel, Publisher: Birkhauser-Verlag, Pages: 247-268
  • Journal article
    Dell A, 2002,

    Structures of glycoprotein glycans

    , AUSTRALIAN JOURNAL OF CHEMISTRY, Vol: 55, Pages: 27-37, ISSN: 0004-9425
  • Book chapter
    Wisden W, Farrant M, 2002,

    Insights into GABA-A receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors.

    , Glutamate and GABA receptors and transporters, Editors: Egebjerg, Krogsgaard-Larsen, Schousboe, Publisher: CRC, Pages: 189-201, ISBN: 9780748408818

    This book conveys recent discoveries in a framework of the basic concepts in the fieldof glutamate and GABA receptor research.
  • Book chapter
    van Thor JJ, Gensch T, Hellingwerf KJ, Johnson LNet al., 2002,

    Phototransformation of the wildtype green fluorescent protein with UVV- and Visible light leads to decarboxylation of glutamate 222

    , Bioluminescence & chemiluminescence, Editors: Stanley, Kricka, Publisher: World Scientific Pub Co Inc, ISBN: 9789812381569

    This volume presents a compilation of the latest developments from key experts and leading-edge researchers in this area.
  • Journal article
    Stapley BJ, Kelley LA, Sternberg MJE, 2002,

    Predicting the sub-cellular location of proteins from text using support vector machines.

    , Pac Symp Biocomput, Pages: 374-385, ISSN: 2335-6928

    We present an automatic method to classify the sub-cellular location of proteins based on the text of relevant medline abstracts. For each protein, a vector of terms is generated from medline abstracts in which the protein/gene's name or synonym occurs. A Support Vector Machine (SVM) is used to automatically partition the term space and to thus discriminate the textual features that define sub-cellular location. The method is benchmarked on a set of proteins of known sub-cellular location from S. cerevisiae. No prior knowledge of the problem domain nor any natural language processing is used at any stage. The method out-performs support vector machines trained on amino acid composition and has comparable performance to rule-based text classifiers. Combining text with protein amino-acid composition improves recall for some sub-cellular locations. We discuss the generality of the method and its potential application to a variety of biological classification problems.
  • Journal article
    Dionne MS, Schneider DS, 2002,

    Screening the fruitfly immune system.

    , Genome Biol, Vol: 3

    The anti-microbial defense system of Drosophila shows functional similarities with the vertebrate innate immune system. Two recent gene-expression profiling studies of fruitflies challenged with infectious agents have identified key molecular players in the fruitfly's response to bacterial and fungal infection, as well as a large number of immune-regulated genes with unknown immunological function.
  • Journal article
    Drickamer K, Taylor ME, 2002,

    Glycan arrays for functional glycomics

    , GENOME BIOLOGY, Vol: 3, ISSN: 1474-760X
  • Book chapter
    McCann FE, Suhling K, Carlin LM, Eleme K, Yanagi K, French PMW, Phillips D, Davis DMet al., 2002,

    Probing supramolecular organisation at immune synapses

    , Editors: Templer, Leatherbarrow, Cambridge, Publisher: Royal Society of Chemistry, Pages: 58-71, ISBN: 9780854048519
  • Book chapter
    Matthews S, 2002,

    NMR of proteins and nucleic acids

    , RSc Special Periodical Reports, Editors: Webb, Pages: 312-332
  • Journal article
    Nieduszynski CA, Murray J, Carrington M, 2002,

    Whole-genome analysis of animal A- and B-type cyclins

    , Genome Biology, Vol: 3, Pages: research0070.1-research0070.8.

    BACKGROUND: Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene. Complete sequencing of several animal genomes has allowed us to determine the size of the mitotic cyclin gene family and therefore to start to address this issue. RESULTS: We analyzed the Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens genomes to identify known and novel A- and B-type cyclin genes and distinguish them from related pseudogenes. We find only a single functional A-type cyclin gene in invertebrates but two in vertebrates. In addition to the single functional cyclin A gene, the C. elegans genome contains numerous cyclin A pseudogenes. In contrast, the number and relationship of B-type cyclins varies considerably between organisms but all contain at least one cyclin B1-like gene and a cyclin B3 gene. CONCLUSIONS: There are three conserved families of mitotic cyclins in animals: A-, B3- and B-type. The precise number of genes within the A- and B-type families varies in different organisms, possibly as an adaptation to their distinct developmental strategies.
  • Conference paper
    Webster AJ, Purvis A, 2002,

    Ancestral states and evolutionary rates of continuous characters

    , London, Publisher: Taylor and Francis, Pages: 247-268
  • Journal article
    Moreira LA, Ito J, Ghosh A, Devenport M, Zieler H, Abraham EG, Crisanti A, Nolan T, Catteruccia F, Jacobs-Lorena Met al., 2002,

    Bee venom phospholipase inhibits malaria parasite development in transgenic mosquitoes

    , Journal of Biological Chemistry, Vol: 277, Pages: 40839-40843
  • Journal article
    Purvis A, 2002,

    Adapting to a diverse world: Organisms, Diversity and Evolution [journal review]

    , Nature, Vol: 420, Pages: 22-23
  • Conference paper
    Finn RD, Orlova EV, van Heel M, Buck Met al., 2002,

    Structures of multisubunit DNA-dependent RNA polymerases

    , 61st Symposium of the Society-for-General-Microbiology, Publisher: CAMBRIDGE UNIV PRESS, Pages: 73-103, ISSN: 0081-1394

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