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  • Journal article
    Chik HYJ, Sibma A, Mannarelli M-E, dos Remedios N, Simons MJP, Burke T, Dugdale HL, Schroeder Jet al., 2024,

    Heritability and age-dependent changes in genetic variation of telomere length in a wild house sparrow population

    , EVOLUTION LETTERS
  • Journal article
    Maurenza D, Crouzeilles R, Prevedello JA, Almeida-Gomes M, Schmoeler M, Pardini R, Banks-Leite C, Vieira MV, Metzger JP, Fonseca CR, Zanin M, Mendes AF, Boesing AL, Rezende AA, Filgueiras BKC, Barros CDSD, Estavillo C, Peres CA, Esteves CF, Rigueira D, Faria D, Mariano-Neto E, Cazetta E, Capellesso ES, Vieira EM, Hasui E, Junior EMSS, Ramos FN, Gomes FS, Paise G, Leal IR, Morante-Filho JC, Bogoni JA, Ferraz KMPMDB, Rocha-Santos L, Reis LCD, Querido LCDA, Magnago LFS, Santos LGRO, Passamani M, Tabarelli M, Marques MCM, Lima MM, Matos MA, Graipel ME, Silveira MS, Pessoa MDS, Safar NVH, Brancalion PHS, Porto TJ, Puttker Tet al., 2024,

    Effects of deforestation on multitaxa community similarity in the Brazilian Atlantic Forest

    , CONSERVATION BIOLOGY, ISSN: 0888-8892
  • Journal article
    Gahlot DK, Patkowski JB, Fernández de Santaella J, Allsopp LP, Pan Z, Filloux A, Larrouy-Maumus G, Francis MS, Costa TRDet al., 2024,

    Cpx-signalling in Yersinia pseudotuberculosis modulates Lipid-A remodelling and resistance to last-resort antimicrobials

    , npj Antimicrobials and Resistance, Vol: 2, ISSN: 2731-8745

    Antibiotic resistance is a global healthcare crisis. Bacteria are highly adaptable and can rapidly acquire mechanisms of resistance towards conventional antibiotics. The permeability barrier conferred by the Gram-negative bacteria cell envelope constitutes a first line of defence against the action of antibiotics. Exposure to extracytoplasmic stresses can negatively affect cell envelope homoeostasis and this causes localised protein misfolding, compromised envelope integrity and impairs barrier function. The CpxA-CpxR two-component regulatory system has evolved to sense extracytoplasmic stresses and to regulate processes that restore homoeostasis of the cell envelope. Hence, controlled Cpx-signalling assists bacteria in adapting, surviving and proliferating in harsh environments, including exposure to antibiotics. Herein, we determined that an intact Cpx-signalling is key to maintaining the Yersinia pseudotuberculosis resistance to colistin and polymyxin B. The susceptibility displayed by Cpx-signalling defective mutants, correlated with cell-envelope deformity and specific modifications of Lipid-A. In vivo transcriptional analysis and in vitro protein-DNA binding studies demonstrated that these modifications were dependent on the direct regulation of Lipid-A biogenesis and modifications of operons by the active phosphorylated CpxR~P isoform. Altogether, our work defines the regulatory mechanism that enables Cpx-signalling to actively control cell envelope remodelling and the permeability of antibiotics in the clinically relevant enteropathogen Y. pseudotuberculosis.
  • Journal article
    Majumdar A, Upadhyay MK, Ojha M, Biswas R, Dey S, Sarkar S, Moulick D, Niazi NK, Rinklebe J, Huang J-H, Roychowdhury Tet al., 2024,

    A critical review on the organo-metal(loid)s pollution in the environment: Distribution, remediation and risk assessment

    , SCIENCE OF THE TOTAL ENVIRONMENT, Vol: 951, ISSN: 0048-9697
  • Journal article
    Marshall EKP, Nunes C, Burbaud S, Vincent CM, Munroe NO, Simoes da Silva CJ, Wadhawan A, Pearson WH, Sangen J, Boeck L, Floto RA, Dionne Met al., 2024,

    Microbial metabolism disrupts cytokine activity to impact host immune response

    , Proceedings of the National Academy of Sciences of USA, Vol: 121, ISSN: 0027-8424

    Host–pathogen interactions are shaped by the metabolic status of both the host and pathogen. The host must regulate metabolism to fuel the immune response, while the pathogen must extract metabolic resources from the host to enable its own survival. In this study, we focus on the metabolic interactions of Mycobacterium abscessus with Drosophila melanogaster. We identify MAB_1132c as an asparagine transporter required for pathogenicity in M. abscessus. We show that this requirement is specifically associated with damage to the host: flies infected with MAB_1132c knockout bacteria, or with wild-type bacteria grown in asparagine-restricted conditions, are longer lived without showing a significant change in bacterial load. This is associated with a reduction in the host innate immune response, demonstrated by the decreased transcription of antimicrobial peptides as well as a significant reduction in the ability of the infection to disrupt systemic insulin signaling. Much of the increase in host survival during infection with asparagine-limited M. abscessus can be attributed to alterations in unpaired cytokine signaling. This demonstrates that asparagine transport in M. abscessus prior to infection is not required for replicative fitness in vivo but does significantly influence the interaction with the host immune responses.
  • Thesis dissertation
    Irakleidi DA, 2024,

    The Rtc RNA Repair System in E. coli: underlying molecular regulation and its role in infection and antibiotic resistance.

    The Rtc RNA repair system, comprising of the RNA cyclase RtcA, the RNA ligase RtcB and the transcriptional activator RtcR, is present in many bacterial species causing human diseases, including the model organisms and putative pathogens Escherichia coli and Salmonella enterica, and has been suggested to play a role in the development of antibiotic resistance. Here we explore the events underlying Rtc activation via RtcR and its CRISPR-associated Rossmann fold (CARF) domain as well as its physiological role during infection. In vitro transcription and ATPase assays showcased the inherent inhibition exerted by the RtcR CARF domain towards RtcR activation as well as its recognition of 2’,3’cP RNA termini – known to act as substrates for the system’s ligase, RtcB – as inducing ligands. End-labelling as well as adapter ligation with RtcB of in vivo bound RNA extracts derived from wildtype or N-terminal truncated RtcR provides evidence for the in vivo association of 2’,3’cP-RNA molecules with RtcR. Β-galactosidase assays demonstrated more prominent rtcBA expression in the rtc-inducing ΔhisT and Δrna E. coli mutants when compared to the wildtype, regardless of nutrient abundance. rtcBA expression appears at least partly RtcR-dependent, relying on certain inverted repeats, possibly carrying RtcR binding sites, located at specific positions in the rtcBA promoter. Pathogenicity assays using the infection model G. mellonella demonstrated that wildtype E. coli K12 MG1655 cells are more virulent in vivo compared to variants lacking any of the Rtc components or the functionally important RtcR CARF domain. Complementation of rtc gene deletions with wildtype Rtc proteins, but not functionally catalytic mutants, reverses the infection phenotype to that of wildtype. Post-infection treatment of larvae with the ribosome-targeting antibiotics chloramphenicol and tetracycline fails at affecting the survival rates of larvae infect
  • Journal article
    Thorpe P, Altmann S, Lopez-Cobollo R, Iqbal J, Kanvil S, Simon J-C, Carolan J, Bos J, Turnbull Cet al., 2024,

    Multi-omics approaches define novel aphid effector candidates associated with virulence and avirulence phenotypes

    , BMC Genomics, Vol: 25, ISSN: 1471-2164

    BackgroundCompatibility between plant parasites and their hosts is genetically determined {Citation}both interacting organisms. For example, plants may carry resistance (R) genes or deploy chemical defences. Aphid saliva contains many proteins that are secreted into host tissues. Subsets of these proteins are predicted to act as effectors, either subverting or triggering host immunity. However, associating particular effectors with virulence or avirulence outcomes presents challenges due to the combinatorial complexity. Here we use defined aphid and host genetics to test for co-segregation of expressed aphid transcripts and proteins with virulent or avirulent phenotypes.ResultsWe compared virulent and avirulent pea aphid parental genotypes, and their bulk segregant F1 progeny on Medicago truncatula genotypes carrying or lacking the RAP1 (Resistance to Acyrthosiphon pisum 1) resistance quantitative trait locus. Differential gene expression analysis of whole body and head samples, in combination with proteomics of saliva and salivary glands, enabled us to pinpoint proteins associated with virulence or avirulence phenotypes. There was relatively little impact of host genotype, whereas large numbers of transcripts and proteins were differentially expressed between parental aphids, likely a reflection of their classification as divergent biotypes within the pea aphid species complex. Many fewer transcripts intersected with the equivalent differential expression patterns in the bulked F1 progeny, providing an effective filter for removing genomic background effects. Overall, there were more upregulated genes detected in the F1 avirulent dataset compared with the virulent one. Some genes were differentially expressed both in the transcriptome and in the proteome datasets, with aminopeptidase N proteins being the most frequent differentially expressed family. In addition, a substantial proportion (27%) of salivary proteins lack annotations, suggesting that many novel functi
  • Journal article
    Lázaro IA, Anastasaki A, Ardoña HAM, Arguilla MQ, Bati ASR, Batmunkh M, Besford QA, Browne MP, Bryant SJ, Carlotti M, Contini C, Delaney C, Draper ER, Elbourne A, Evans JD, Florea L, Forner-Cuenca A, Forse AC, Gonzalez MI, Krause S, Lee HK, Lerch MM, Liu S, López-Salas N, Martin-Martinez FJ, Pezzato C, Protesescu L, Schaufelberger F, Pascual PS, Fernández AS, Tarpeh WA, Vilé G, von Krbek LKS, Wang H, Wu T, Wells CJR, Cranford SWet al., 2024,

    35 challenges in materials science being tackled by PIs under 35(ish) in 2024

    , Matter, Vol: 7, Pages: 3699-3706, ISSN: 2590-2385

    Here, we highlight 35 global researchers approximately under the age of 35. This third annual cohort was self-generated by initial seed invitations sent by the editorial team, with each contributor suggesting two more in a nominally supervised self-selecting pyramid-like scheme. The final collection reflects both the diversity and excitement across the field of materials science.
  • Journal article
    Zhang-Zheng H, Deng X, Aguirre-Gutierrez J, Stocker B, Thomson E, Ding R, Adu Bredu S, Duah-Gyamfi A, Gvozdevaite A, Moore S, Oliveras Menor I, Prentice IC, Malhi Yet al., 2024,

    Why models underestimate West African tropical forest primary productivity

    , Nature Communications, Vol: 15, ISSN: 2041-1723

    Tropical forests dominate terrestrial photosynthesis, yet there are major contradictions in our understanding due to a lack of field studies, especially outside the tropical Americas. A recent field study indicated that West African forests have among the highest forests gross primary productivity (GPP) yet observed, contradicting models that rank them lower than Amazonian forests. Here, we show possible reasons for this data-model mismatch. We found that biometric GPP measurements are on average 56.3% higher than multiple global GPP products at the study sites. The underestimation of GPP largely disappears when a standard photosynthesis model is informed by local field-measured values of (a) fractional absorbed photosynthetic radiation (fAPAR), and (b) photosynthetic traits. Remote sensing products systematically underestimate fAPAR (33.9% on average at study sites) due to cloud contamination issues. The study highlights the potential widespread underestimation of tropical forests GPP and carbon cycling and hints at the ways forward for model and input data improvement.
  • Conference paper
    Millar J, Sethi S, Haddadi H, Madhavapeddy Aet al., 2024,

    Poster: Towards Low-Power Comprehensive Biodiversity Monitoring

    , Pages: 844-846

    The Kunming-Montreal Global Biodiversity Framework sets ambitious targets for 2023, including halting human-induced species extinction. Achieving these requires comprehensive data on global biodiversity patterns, which can only be gathered through in-situ distributed sensor networks. However, these multi-device networks are constrained by battery lifetimes, must gather rich data from power-hungry sensors, and yet need to be deployed in remote environments for long periods. This note introduces a prototype multi-sensor device, and outlines how embedded scheduling could be used for extending sensor lifetime and resource-efficiency.
  • Journal article
    Liu Y, Chen JM, Xu M, Wang R, Fan W, Li W, Kammer L, Prentice C, Keenan TF, Smith NGet al., 2024,

    Improved global estimation of seasonal variations in C3 photosynthetic capacity based on eco-evolutionary optimality hypotheses and remote sensing

    , REMOTE SENSING OF ENVIRONMENT, Vol: 313, ISSN: 0034-4257
  • Journal article
    Selles J, Alric J, Rutherford AW, Davis GA, Viola Set al., 2024,

    In vivo ElectroChromic Shift measurements of photosynthetic activity in far-red absorbing cyanobacteria

    , BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1865, ISSN: 0005-2728
  • Journal article
    Benjamin S, Jégouzo S, Lieng C, Daniels C, Coispeau M, Lau R, Kim S, Metaxa Y, Philpott J, Li T, Dai C, Wang X, Newby M, Pier G, Crispin M, Clements A, Taylor M, Drickamer Ket al., 2024,

    A human lectin array for characterizing host-pathogen interactions

    , Journal of Biological Chemistry, Vol: 300, ISSN: 0021-9258

    A human lectin array has been developed to probe the interactions of innate immune receptors with pathogenic and commensal micro-organisms. Following the successful introduction of a lectin array containing all of the cow C-type carbohydrate-recognition domains (CRDs), a human array described here contains the C-type CRDs as well as CRDs from other classes of sugar-binding receptors, including galectins, siglecs, R-type CRDs, ficolins, intelectins and chitinase-like lectins. The array is constructed with CRDs modified with single-site biotin tags, ensuring that the sugar-binding sites in CRDs are displayed on a streptavidin-coated surface in a defined orientation and are accessible to the surfaces of microbes. A common approach used for expression and display of CRDs from all of the different structural categories of glycan-binding receptors allows comparisons across lectin families. In addition to previously documented protocols for binding of fluorescently-labeled bacteria, methods have been developed for detecting unlabeled bacteria bound to the array by counter-staining with DNA binding dye. Screening has also been undertaken with viral glycoproteins and bacterial and fungal polysaccharides. The array provides an unbiased screen for sugar ligands that interact with receptors and many show binding not anticipated from earlier studies. For example, some of the galectins bind with high affinity to bacterial glycans that lack lactose or N acetyllactosamine. The results demonstrate the utility of the human lectin array for providing a unique overview of the interactions of multiple classes of glycan-binding proteins in the innate immune system with different types of micro-organisms.
  • Journal article
    Prentice IC, Balzarolo M, Bloomfield KJ, Chen JM, Dechant B, Ghent D, Janssens IA, Luo X, Morfopoulos C, Ryu Y, Vicca S, van Hoolst Ret al., 2024,

    Principles for satellite monitoring of vegetation carbon uptake

    , Nature Reviews Earth & Environment, Vol: 5, ISSN: 2662-138X

    Remote sensing-based numerical models harness satellite-borne measurements of light absorption by vegetation to estimate global patterns and trends in gross primary production (GPP)—the basis of the terrestrial carbon cycle. In this Perspective, we discuss the challenges in estimating GPP using these models and explore ways to improve their reliability. Current models vary substantially in their structure and produce differing results, especially as regards temporal trends in GPP. Many models invoke the light use efficiency (LUE) principle, which links light absorption to photosynthesis and plant biomass production, to estimate GPP. But these models vary in their assumptions about the controls of LUE and typically depend on many, poorly known parameters. Eco-evolutionary optimality principles can greatly reduce parameter requirements, and can improve the accuracy and consistency of GPP estimates and interpretations of their relationships with environmental drivers. Integrating data across different satellites and sensors, and utilising auxiliary optical band retrievals, could enhance spatiotemporal resolution and improve models' ability to detect aspects of vegetation physiology, including drought stress. Extending and harmonizing the eddy-covariance flux tower network will support systematic evaluation of GPP models. Enhancing the reliability of GPP and biomass production estimates will better characterise temporal variation and improve understanding of the terrestrial carbon cycle’s response to environmental change.
  • Journal article
    Ewers RM, 2024,

    An audacious approach to conservation

    , TRENDS IN ECOLOGY & EVOLUTION, Vol: 39, Pages: 995-1003, ISSN: 0169-5347
  • Journal article
    Qi M, Suz LM, Bidartondo MI, Orme CDL, Delhaye G, Openshaw I, Tovar Cet al., 2024,

    Fruitbody and root data infer different environmental niches for ectomycorrhizal fungi

    , JOURNAL OF BIOGEOGRAPHY, Vol: 51, Pages: 2221-2236, ISSN: 0305-0270
  • Journal article
    Williams J, Pettorelli N, Dowell R, Macdonald K, Meyer C, Steyaert M, Tweedt S, Ransome Eet al., 2024,

    SimpleMetaPipeline: Breaking the bioinformatics bottleneck in metabarcoding

    , METHODS IN ECOLOGY AND EVOLUTION, Vol: 15, Pages: 1949-1957, ISSN: 2041-210X
  • Journal article
    Oikawa K, Fujisaki K, Shimizu M, Takeda T, Nemoto K, Saitoh H, Hirabuchi A, Hiraka Y, Miyaji N, Bialas A, Langner T, Kellner R, Bozkurt TO, Cesari S, Kroj T, Banfield MJ, Kamoun S, Terauchi Ret al., 2024,

    The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunity

    , PLOS PATHOGENS, Vol: 20, ISSN: 1553-7366
  • Journal article
    Madhuprakash J, Toghani A, Contreras MP, Posbeyikian A, Richardson J, Kourelis J, Bozkurt TO, Webster MW, Kamoun Set al., 2024,

    A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity

    , Science Advances, Vol: 10, ISSN: 2375-2548

    NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute immune responses triggered by sensor NLRs. The resting state of NbNRC2 was recently shown to be a homodimer, but the sensor-activated state remains unclear. Using cryo-EM, we determined the structure of sensor-activated NbNRC2, which forms a hexameric inflammasome-like resistosome. Mutagenesis of the oligomerization interface abolished immune signaling, confirming the functional significance of the NbNRC2 resistosome. Comparative structural analyses between the resting state homodimer and sensor-activated homohexamer revealed substantial rearrangements, providing insights into NLR activation mechanisms. Furthermore, structural comparisons between NbNRC2 hexamer and previously reported CC-NLR pentameric assemblies revealed features allowing an additional protomer integration. Using the NbNRC2 hexamer structure, we assessed the recently released AlphaFold 3 for predicting activated CC-NLR oligomers, revealing high-confidence modeling of NbNRC2 and other CC-NLR amino-terminal α1 helices, a region proven difficult to resolve structurally. Overall, our work sheds light on NLR activation mechanisms and expands understanding of NLR structural diversity.
  • Journal article
    Barber RA, Yang J, Yang C, Barker O, Janicke T, Tobias JAet al., 2024,

    Climate and ecology predict latitudinal trends in sexual selection inferred from avian mating systems

    , PLOS BIOLOGY, Vol: 22, ISSN: 1544-9173
  • Journal article
    Williams J, Newbold T, Millard J, Comyn-Platt V, Pearson Ret al., 2024,

    Important Crop Pollinators Respond Less Negatively to Anthropogenic Land Use Than Other Animals

    , Ecology and Evolution, ISSN: 2045-7758

    Animal-mediated pollination is a key ecosystem service required to some extent by almost three-quarters of the leading human food crops in global food production. Anthropogenic pressures such as habitat loss and land-use intensification are causing shifts in ecological community composition, potentially resulting in declines in pollination services and impacting crop production. Previous research has often overlooked interspecific differences in pollination contribution, yet such differences mean that biodiversity declines will not necessarily negatively impact pollination. Here, we use a novel species-level ecosystem service contribution matrix along with mixed-effects models to explore how groups of terrestrial species who contribute differently to crop pollination respond globally to land-use type, land-use intensity, and availability of natural habitats in the surrounding landscape. We find that the species whose contribution to crop pollination is higher generally respond less negatively (and in some cases positively) to human disturbance of land, compared to species that contribute less or not at all to pollination. This result may be due to these high-contribution species being less sensitive to anthropogenic land conversions, which has led humans to being more reliant on them for crop pollination. However, it also suggests that there is potential for crop pollination to be resilient in the face of anthropogenic land conversions. With such a high proportion of food crops requiring animal-mediated pollination to some extent, understanding how anthropogenic landscapes impact ecological communities and the consequences for pollination is critical for ensuring food security.
  • Journal article
    Cheong B, Tang W, Kostrzewa M, Larrouy-Maumus Get al., 2024,

    Use of stable isotope combined with intact cell lipidomic by routine MALDI mass spectrometry analysis for rapid drug susceptibility assay in mycobacteria

    , RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 38, ISSN: 0951-4198
  • Journal article
    Schroeder J, Dunning J, Chan AHH, Chik HYJ, Burke Tet al., 2024,

    Not so social in old age: demography as one driver of decreasing sociality

    , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 379, ISSN: 0962-8436
  • Conference paper
    Ruotolo I, Saglietto A, Saturi G, Sena G, Ponziani A, Parisi V, Ditaranto R, Zaccaro A, Casale M, Schiavo MA, Longhi S, Galie' N, Raineri C, De Ferrari GM, Biagini Eet al., 2024,

    Artificial intelligence (AI)-enhanced electrocardiography: a machine-learning model for differential diagnosis between hypertrophic cardiomyopathy, cardiac amyloidosis and Anderson-Fabry disease

    , European-Society-of-Cardiology Congress (ESC), Publisher: OXFORD UNIV PRESS, ISSN: 0195-668X
  • Conference paper
    Di Nicola F, Barile L, Schiavo MA, Sena G, Ruotolo I, Catalano C, Parisi V, Fanciullo N, Barlocco F, Lillo R, Re F, Graziani F, Galie' N, Olivotto I, Biagini Eet al., 2024,

    Anderson-Fabry disease patients with anatomical heart hypertrophy express a higher degree of electrocardiographic hypertrophy compared to hypertrophic cardiomyopathy patients

    , European-Society-of-Cardiology Congress (ESC), Publisher: OXFORD UNIV PRESS, ISSN: 0195-668X
  • Journal article
    Selvaraj M, Toghani A, Pai H, Sugihara Y, Kourelis J, Yuen ELH, Ibrahim T, Zhao H, Xie R, Maqbool A, De la Concepcion JC, Banfield MJ, Derevnina L, Petre B, Lawson DM, Bozkurt TO, Wu C-H, Kamoun S, Contreras MPet al., 2024,

    Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

    , PLoS Biology, Vol: 22, ISSN: 1544-9173

    Nucleotide-binding domain and leucine-rich repeat (NLR) proteins can engage in complex interactions to detect pathogens and execute a robust immune response via downstream helper NLRs. However, the biochemical mechanisms of helper NLR activation by upstream sensor NLRs remain poorly understood. Here, we show that the coiled-coil helper NLR NRC2 from Nicotiana benthamiana accumulates in vivo as a homodimer that converts into a higher-order oligomer upon activation by its upstream virus disease resistance protein Rx. The cryo-EM structure of NbNRC2 in its resting state revealed intermolecular interactions that mediate homodimer formation and contribute to immune receptor autoinhibition. These dimerization interfaces have diverged between paralogous NRC proteins to insulate critical network nodes and enable redundant immune pathways, possibly to minimise undesired cross-activation and evade pathogen suppression of immunity. Our results expand the molecular mechanisms of NLR activation pointing to transition from homodimers to higher-order oligomeric resistosomes.
  • Journal article
    Hancock PA, North A, Leach AW, Winskill P, Ghani AC, Godfray HCJ, Burt A, Mumford JDet al., 2024,

    The potential of gene drives in malaria vector species to control malaria in African environments

    , NATURE COMMUNICATIONS, Vol: 15
  • Journal article
    Kontopoulos D-G, Sentis A, Daufresne M, Pawar Set al., 2024,

    No universal mathematical model for thermal performance curves across traits and taxonomic groups

    , Nature Communications, Vol: 15, ISSN: 2041-1723

    In ectotherms, the performance of physiological, ecological and life-history traits universally increases with temperature to a maximum before decreasing again. Identifying the most appropriate thermal performance model for a specific trait type has broad applications, from metabolic modelling at the cellular level to forecasting the effects of climate change on population, ecosystem and disease transmission dynamics. To date, numerous mathematical models have been designed, but a thorough comparison among them is lacking. In particular, we do not know if certain models consistently outperform others and how factors such as sampling resolution and trait or organismal identity influence model performance. To fill this knowledge gap, we compile 2,739 thermal performance datasets from diverse traits and taxa, to which we fit a comprehensive set of 83 existing mathematical models. We detect remarkable variation in model performance that is not primarily driven by sampling resolution, trait type, or taxonomic information. Our results reveal a surprising lack of well-defined scenarios in which certain models are more appropriate than others. To aid researchers in selecting the appropriate set of models for any given dataset or research objective, we derive a classification of the 83 models based on the average similarity of their fits.
  • Journal article
    Masignani V, Rappuoli R, Pizza M, 2024,

    Next generation of "magic bullets", solutions from the microbial pangenome

    , EMBO MOLECULAR MEDICINE, Vol: 16, Pages: 2271-2273, ISSN: 1757-4676
  • Journal article
    Gaboriau T, Tobias JA, Silvestro D, Salamin Net al., 2024,

    Exploring the Macroevolutionary Signature of Asymmetric Inheritance at Speciation

    , SYSTEMATIC BIOLOGY, ISSN: 1063-5157

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