BibTex format
@article{Leong:2022:10.15252/embj.2021110352,
author = {Leong, JX and Raffeiner, M and Spinti, D and Langin, G and Franz-Wachtel, M and Guzman, AR and Kim, J-G and Pandey, P and Minina, AE and Macek, B and Hafren, A and Bozkurt, TO and Mudgett, MB and Boernke, F and Hofius, D and Uestuen, S},
doi = {10.15252/embj.2021110352},
journal = {The EMBO Journal},
title = {A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component},
url = {http://dx.doi.org/10.15252/embj.2021110352},
volume = {41},
year = {2022}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Beyond its role in cellular homeostasis, autophagy plays anti and promicrobial roles in host–microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although welldescribed in animals, the extent to which xenophagy contributes to plant–bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing typeIII effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defenserelated selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defenserelated autophagy in plant–bacteria interactions.
AU - Leong,JX
AU - Raffeiner,M
AU - Spinti,D
AU - Langin,G
AU - Franz-Wachtel,M
AU - Guzman,AR
AU - Kim,J-G
AU - Pandey,P
AU - Minina,AE
AU - Macek,B
AU - Hafren,A
AU - Bozkurt,TO
AU - Mudgett,MB
AU - Boernke,F
AU - Hofius,D
AU - Uestuen,S
DO - 10.15252/embj.2021110352
PY - 2022///
SN - 0261-4189
TI - A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component
T2 - The EMBO Journal
UR - http://dx.doi.org/10.15252/embj.2021110352
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000800471300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL - 41
ER -