In this section
@article{Schulte:2011:10.1038/emboj.2011.94,
author = {Schulte, LN and Eulalio, A and Mollenkopf, HJ and Reinhardt, R and Vogel, J},
doi = {10.1038/emboj.2011.94},
journal = {EMBO J},
pages = {1977--1989},
title = {Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family},
url = {http://dx.doi.org/10.1038/emboj.2011.94},
volume = {30},
year = {2011}
}
TY - JOUR
AB - MicroRNAs have well-established roles in eukaryotic host responses to viruses and extracellular bacterial pathogens. In contrast, microRNA responses to invasive bacteria have remained unknown. Here, we report cell type-dependent microRNA regulations upon infection of mammalian cells with the enteroinvasive pathogen, Salmonella Typhimurium. Murine macrophages strongly upregulate NF-kappaB associated microRNAs; strikingly, these regulations which are induced by bacterial lipopolysaccharide (LPS) occur and persist regardless of successful host invasion and/or replication, or whether an inflammatory response is mounted, suggesting that microRNAs belong to the first line of anti-bacterial defence. However, a suppression of the global immune regulator miR-155 in endotoxin-tolerant macrophages revealed that microRNA responses also depend on the status of infected cells. This study identifies the let-7 family as the common denominator of Salmonella-regulated microRNAs in macrophages and epithelial cells, and suggests that repression of let-7 relieves cytokine IL-6 and IL-10 mRNAs from negative post-transcriptional control. Our results establish a paradigm of microRNA-mediated feed-forward activation of inflammatory factors when mammalian cells are targeted by bacterial pathogens.
AU - Schulte,LN
AU - Eulalio,A
AU - Mollenkopf,HJ
AU - Reinhardt,R
AU - Vogel,J
DO - 10.1038/emboj.2011.94
EP - 1989
PY - 2011///
SN - 1460-2075
SP - 1977
TI - Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family
T2 - EMBO J
UR - http://dx.doi.org/10.1038/emboj.2011.94
UR - https://www.ncbi.nlm.nih.gov/pubmed/21468030
VL - 30
ER -
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