In this section
@article{Martinez:2022:10.1038/s43587-022-00312-x,
author = {Martinez, Corrales G and Li, M and Svermova, T and Goncalves, A and Voicu, D and Dobson, AJ and Southall, TD and Alic, N},
doi = {10.1038/s43587-022-00312-x},
journal = {Nature Aging},
pages = {1176--1190},
title = {Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1},
url = {http://dx.doi.org/10.1038/s43587-022-00312-x},
volume = {2},
year = {2022}
}
TY - JOUR
AB - A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal aging as animals encounter a multitude of diverse stimuli throughout their lifespan. Here we show that activating an evolutionarily conserved, longevity-promoting transcription factor, dFOXO, solely in early adulthood of female fruit flies is sufficient to improve their subsequent health and survival in midlife and late life. This youth-restricted dFOXO activation causes persistent changes to chromatin landscape in the fat body and requires chromatin remodelers such as the SWI/SNF and ISWI complexes to program health and longevity. Chromatin remodeling is accompanied by a long-lasting transcriptional program that is distinct from that observed during acute dFOXO activation and includes induction of Xbp1. We show that this later-life induction of Xbp1 is sufficient to curtail later-life mortality. Our study demonstrates that transcriptional memory can profoundly alter how animals age.
AU - Martinez,Corrales G
AU - Li,M
AU - Svermova,T
AU - Goncalves,A
AU - Voicu,D
AU - Dobson,AJ
AU - Southall,TD
AU - Alic,N
DO - 10.1038/s43587-022-00312-x
EP - 1190
PY - 2022///
SN - 2662-8465
SP - 1176
TI - Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1
T2 - Nature Aging
UR - http://dx.doi.org/10.1038/s43587-022-00312-x
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000916582800017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL - 2
ER -
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