In this section
@article{Gasperini:2017:10.2217/fmb-2017-0064,
author = {Gasperini, G and Arato, V and Pizza, M and Aricò, B and Leuzzi, R},
doi = {10.2217/fmb-2017-0064},
journal = {Future Microbiol},
pages = {1247--1259},
title = {Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis.},
url = {http://dx.doi.org/10.2217/fmb-2017-0064},
volume = {12},
year = {2017}
}
TY - JOUR
AB - AIM: Bordetella pertussis has been shown to release outer membrane vesicles (OMV) both in vitro and in vivo but little is known about their biological role during the initial phases of B. pertussis infection of the airways. RESULTS: We have demonstrated that OMV are released by B. pertussis in a human ciliated-airway cell model and purified vesicles can interact with host cells. Binding and uptake are strictly Bvg-regulated and OMV-associated pertussis toxin contributes to host-cell intoxication. Furthermore, we have shown that OMV act as iron-delivery systems complementing the B. pertussis growth defect in iron-limiting conditions. CONCLUSION: We have proved that OMV play different roles in B. pertussis physiopathology and we opened new perspectives to be further investigated.
AU - Gasperini,G
AU - Arato,V
AU - Pizza,M
AU - Aricò,B
AU - Leuzzi,R
DO - 10.2217/fmb-2017-0064
EP - 1259
PY - 2017///
SP - 1247
TI - Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis.
T2 - Future Microbiol
UR - http://dx.doi.org/10.2217/fmb-2017-0064
UR - https://www.ncbi.nlm.nih.gov/pubmed/28980823
VL - 12
ER -
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