In this section
@article{Cummins:2021:10.1002/ejp.1681,
author = {Cummins, TM and McMahon, SB and Bannister, K},
doi = {10.1002/ejp.1681},
journal = {European Journal of Pain},
pages = {415--429},
title = {The impact of paradigm and stringent analysis parameters on measuring a net conditioned pain modulation effect: A test, retest, control study},
url = {http://dx.doi.org/10.1002/ejp.1681},
volume = {25},
year = {2021}
}
TY - JOUR
AB - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Reporting in conditioned pain modulation (CPM) studies is not standardised. Here, two CPM protocols were performed in populations of healthy human subjects in order to investigate the influence of the CPM paradigm and stringent analyses parameters on the identification of a net CPM effect.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A standard thermal or mechanical CPM protocol was carried out on 25 and 17 subjects, respectively. The standard error of measurement (<jats:italic>SEM</jats:italic>) of the CPM effect was calculated in order to determine a change in pain thresholds greater than that due to measurement error or ‘real’ change in test scores. In addition, each individual underwent a minimum of two control CPM sessions, which were paired with the CPM test sessions. To quantify a net CPM effect, the intrasession difference between baseline and conditioning was subtracted from the difference calculated at the same time points during the control session.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For both protocols, excellent reliability for intrasession repeats of the test stimulus at baseline was demonstrated for thermal and mechanical stimulation (ICC > 0.9). Testretest subject responses (in terms of experimental Session 1 versus. Session 2) showed excellent reliability for mechanical (ICC > 0.8), compared to thermal stimulation, which ranged from poor to moderate (ICC < 0.4>0.75). However, calculating the net CPM effect using control session data demonstrated poorfair reliability for both protocols (ICC < 0.4–0.59).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title>&l
AU - Cummins,TM
AU - McMahon,SB
AU - Bannister,K
DO - 10.1002/ejp.1681
EP - 429
PY - 2021///
SN - 1090-3801
SP - 415
TI - The impact of paradigm and stringent analysis parameters on measuring a net conditioned pain modulation effect: A test, retest, control study
T2 - European Journal of Pain
UR - http://dx.doi.org/10.1002/ejp.1681
UR - https://doi.org/10.1002/ejp.1681
VL - 25
ER -
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