BibTex format
@article{Rukavina:2025:10.1371/journal.pone.0316563,
author = {Rukavina, K and Staunton, J and Zinzalias, P and Krbot, Skoric M and Wu, K and Bannister, K and Rizos, A and Ray, Chaudhuri K},
doi = {10.1371/journal.pone.0316563},
journal = {PLOS ONE},
pages = {e0316563--e0316563},
title = {Wearable devices may aid the recognition of fluctuation-related pain in Parkinson’s disease—An exploratory, cross-sectional analysis of two prospective observational studies},
url = {http://dx.doi.org/10.1371/journal.pone.0316563},
volume = {20},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:p>Fluctuation-related pain (FRP) affects more than one third of people with Parkinson’s disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clinicians. The National Institute for Health and Care Excellence (NICE) recommends The Parkinson KinetiGraph<jats:sup>TM</jats:sup> (the PKG<jats:sup>TM</jats:sup>) for remote monitoring of motor symptoms. We investigated potential links between the PKG<jats:sup>TM</jats:sup>-obtained parameters and clinical rating scores for FRP in PwP in an exploratory, cross-sectional analysis of two prospective studies: “<jats:italic>The Non-motor International Longitudinal</jats:italic>, <jats:italic>Real-Life Study in PD—NILS</jats:italic>” and “<jats:italic>An observational-based registry of baseline PKG™ in PD—PKGReg</jats:italic>”. 63 PwP (41.3% female; age: 64.24±9.88 years; disease duration, DD: 6.83±5.63 years; Hoehn and Yahr Stage, H&Y: 2 (1–4); Levodopa Equivalent Daily Dose 535 (0–3230) mg) were included. PwP with FRP (n = 23) had longer DD (8.88 (1.29–19.05) vs. 3.16 (0.34–28.92), <jats:italic>p</jats:italic> = 0.001), higher severity of motor symptoms (H&Y 3 (1–4) vs. 2 (1–4), <jats:italic>p</jats:italic> = 0.015; SCOPA Motor total score 21.35±10.19 vs. 13.65±8.99, <jats:italic>p</jats:italic> = 0.003), more dyskinesia (SCOPA Motor Item 18 ≥1 60.9% vs. 7.5%, <jats:italic>p</jats:italic><0.001), and worse HRQoL (PDQ-8 Total Score 10.74±5.98 vs. 6.78±5.13, <jats:italic>p</jats:italic> = 0.007) then PwP without FRP (n = 40). In the multivariate logistic regression, after the adjustment for DD, H&Y and SCOPA-Motor total score, the presence
AU - Rukavina,K
AU - Staunton,J
AU - Zinzalias,P
AU - Krbot,Skoric M
AU - Wu,K
AU - Bannister,K
AU - Rizos,A
AU - Ray,Chaudhuri K
DO - 10.1371/journal.pone.0316563
EP - 0316563
PY - 2025///
SP - 0316563
TI - Wearable devices may aid the recognition of fluctuation-related pain in Parkinson’s disease—An exploratory, cross-sectional analysis of two prospective observational studies
T2 - PLOS ONE
UR - http://dx.doi.org/10.1371/journal.pone.0316563
UR - https://doi.org/10.1371/journal.pone.0316563
VL - 20
ER -