In this section
@inbook{Perouansky:2024:10.1016/B978-0-323-93592-0.00017-1,
author = {Perouansky, M and Pearce, RA and Hemmings, HC and Franks, NP},
booktitle = {Miller S Anesthesia 2 Volume Set},
doi = {10.1016/B978-0-323-93592-0.00017-1},
pages = {372--394.e6},
title = {Inhaled Anesthetics: Mechanisms of Action},
url = {http://dx.doi.org/10.1016/B978-0-323-93592-0.00017-1},
year = {2024}
}
TY - CHAP
AB - This chapter reviews current understanding of how inhaled anesthetics exert their effects. These drugs are chemically relatively simple, but diverse, and we review how thinking about their molecular targets has changed radically during the last 50 years from non-specific modes of action to specific inhibition or excitation of ion channels and receptors. To put these mechanisms in context, we show that the anesthetic state should be considered in terms of an integrated change in the state of the central nervous system, by considering the separate components of anesthesia (unconsciousness, sedation, immobility and changes in learning and memory). We then discuss what changes occur at the cellular level during anesthesia and how molecular targets underlying these effects can be identified. We outline the various techniques that have been used to identify likely targets and give the consensus view on what the most likely molecular targets are. Finally, we end by discussing some interesting and promising approaches for future work.
AU - Perouansky,M
AU - Pearce,RA
AU - Hemmings,HC
AU - Franks,NP
DO - 10.1016/B978-0-323-93592-0.00017-1
EP - 394
PY - 2024///
SP - 372
TI - Inhaled Anesthetics: Mechanisms of Action
T1 - Miller S Anesthesia 2 Volume Set
UR - http://dx.doi.org/10.1016/B978-0-323-93592-0.00017-1
ER -
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