BibTex format
@article{Tajadura-Ortega:2025:10.1038/s41467-025-60404-1,
author = {Tajadura-Ortega, V and Chai, W and Roberts, LA and Zhang, Y and Maio, AD and Decout, AC and Pinheiro, BA and Palma, AS and Nicola, GD and Riaposova, L and Gimeno-Molina, B and Lee, YS and Cao, H and Piskarev, V and Akune, Y and Costa, TRD and Amin, H and Sykes, L and Bennett, PR and Marchesi, JR and Feizi, T and Liu, Y and MacIntyre, D},
doi = {10.1038/s41467-025-60404-1},
journal = {Nature Communications},
title = {Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes},
url = {http://dx.doi.org/10.1038/s41467-025-60404-1},
volume = {16},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Lactobacillus displacement from the vaginal microbiome associates with adverse health outcomes and is linked to increased risk of preterm birth. Glycans mediate bacterial adhesion events involved in colonisation and infection. Using customised glycan microarrays, we establish glycan interaction profiles of vaginal bacteria implicated in reproductive health. Glycan binding signatures of the opportunistic pathogens Escherichia coli, Fusobacterium nucleatum and Streptococcus agalactiae to oligomannose N-glycans, galactose-terminating glycans and hyaluronic acid, respectively are highly distinct from Lactobacillus commensals. Binding to sulphated glycosaminoglycans by vaginal bacteria is pH dependent, as is binding to neutral and sialic acid-terminating glycans by F. nucleatum. Adhesion of Lactobacillus crispatus, Lactobacillus iners, Gardnerella vaginalis, S. agalactiae and F. nucleatum to vaginal epithelial cells is partially mediated by chondroitin sulphate. S. agalactiae binding to chondroitin sulphate C oligosaccharides is inhibited by L. crispatus. This study highlights glycans as mediators of vaginal bacterial binding events involved in reproductive health and disease.
AU - Tajadura-Ortega,V
AU - Chai,W
AU - Roberts,LA
AU - Zhang,Y
AU - Maio,AD
AU - Decout,AC
AU - Pinheiro,BA
AU - Palma,AS
AU - Nicola,GD
AU - Riaposova,L
AU - Gimeno-Molina,B
AU - Lee,YS
AU - Cao,H
AU - Piskarev,V
AU - Akune,Y
AU - Costa,TRD
AU - Amin,H
AU - Sykes,L
AU - Bennett,PR
AU - Marchesi,JR
AU - Feizi,T
AU - Liu,Y
AU - MacIntyre,D
DO - 10.1038/s41467-025-60404-1
PY - 2025///
SN - 2041-1723
TI - Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-025-60404-1
UR - https://www.nature.com/articles/s41467-025-60404-1
VL - 16
ER -