BibTex format
@article{Chen:2025:10.1002/advs.202509876,
author = {Chen, H and Xu, Y and Xiong, Z and Wang, H and Wang, X and Kang, Y and Wang, Z and Zeng, X and Liu, Y and Zheng, Y and Chen, W and Li, M and Hu, Z and Xu, C and Wu, Y and Wang, Y and Yuan, Z and Yuan, S and Liu, H and Matthews, S and Qiao, N and Li, Y and Liu, B},
doi = {10.1002/advs.202509876},
journal = {Adv Sci (Weinh)},
title = {Cinnamic-Hydroxamic-Acid Derivatives Exhibit Antibiotic, Anti-Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid-Associated Protein HU.},
url = {http://dx.doi.org/10.1002/advs.202509876},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Finding novel compounds and drug targets is crucial for antibiotic development. The nucleoid-associated protein HU plays a significant role in bacterial DNA metabolism, supercoiling, and biofilm formation, making it a promising new target. In this work, structure-based screening and identified cinnamic-hydroxamic-acid derivatives (CHADs) are conducted as HU inhibitors, with a minimum inhibitory concentration (MIC) of as low as 12 µg mL-1 against a range of pathogenic bacteria. CHADs induce nucleoid deformation, preventing bacterial division and inhibiting growth. They exhibit low toxicity in mice and effectively treat infections in mouse models. Additionally, CHADs possess anti-biofilm activity and supercoiling relaxation properties, countering bacterial stress responses to antibiotics. They suppress changes in gene expression required for optimal stress responses, resulting in synergistic effects with other antibiotics. Thus, CHADs represent a new class of antibiotics that inhibit bacterial stress responses by co-targeting biofilm formation and DNA supercoiling.
AU - Chen,H
AU - Xu,Y
AU - Xiong,Z
AU - Wang,H
AU - Wang,X
AU - Kang,Y
AU - Wang,Z
AU - Zeng,X
AU - Liu,Y
AU - Zheng,Y
AU - Chen,W
AU - Li,M
AU - Hu,Z
AU - Xu,C
AU - Wu,Y
AU - Wang,Y
AU - Yuan,Z
AU - Yuan,S
AU - Liu,H
AU - Matthews,S
AU - Qiao,N
AU - Li,Y
AU - Liu,B
DO - 10.1002/advs.202509876
PY - 2025///
TI - Cinnamic-Hydroxamic-Acid Derivatives Exhibit Antibiotic, Anti-Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid-Associated Protein HU.
T2 - Adv Sci (Weinh)
UR - http://dx.doi.org/10.1002/advs.202509876
UR - https://www.ncbi.nlm.nih.gov/pubmed/41271585
ER -