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@article{Di:1987:10.1016/s0006-291x(87)80199-7,
author = {Di, Marzo V and Tippins, JR and Morris, HR},
doi = {10.1016/s0006-291x(87)80199-7},
journal = {Biochem Biophys Res Commun},
pages = {1213--1218},
title = {Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha.},
url = {http://dx.doi.org/10.1016/s0006-291x(87)80199-7},
volume = {147},
year = {1987}
}
TY - JOUR
AB - The effect of prostaglandins E1 and F1 alpha on peptidoleukotriene biosynthesis/release from rat chopped lung stimulated with platelet activating factor was studied. Prostaglandin E1, known to stimulate adenylate cyclase in airways, inhibited the biosynthesis of leukotrienes C4, D4 and E4 and total peptidoleukotrienes whereas prostaglandin F1 alpha, which has no effect on adenylate cyclase, did not exert any effect on total peptidoleukotriene release, though a small inhibition was found for leukotriene D4. Cyclic AMP itself inhibited peptidoleukotriene release from platelet activating factor-stimulated lung, suggesting that the effect of prostaglandin E1 is mediated by cyclic AMP.
AU - Di,Marzo V
AU - Tippins,JR
AU - Morris,HR
DO - 10.1016/s0006-291x(87)80199-7
EP - 1218
PY - 1987///
SN - 0006-291X
SP - 1213
TI - Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha.
T2 - Biochem Biophys Res Commun
UR - http://dx.doi.org/10.1016/s0006-291x(87)80199-7
UR - https://www.ncbi.nlm.nih.gov/pubmed/2822041
VL - 147
ER -
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