In this section
@article{Ho:2008:10.1074/jbc.M706623200,
author = {Ho, KK and Anderson, AA and Rosivatz, E and Lam, EW and Woscholski, R and Mann, DJ},
doi = {10.1074/jbc.M706623200},
journal = {J.Biol.Chem.},
pages = {5477--5485},
title = {Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network},
url = {http://dx.doi.org/10.1074/jbc.M706623200},
volume = {283},
year = {2008}
}
TY - JOUR
AB - In addition to the well characterized phosphoinositide second messengers derived from the plasma membrane, increasing evidence supports the existence of a nuclear phosphoinositide signaling network. The aim of this investigation was to dissect the role played by nuclear phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) in cell cycle progression and to determine the cell cycle regulatory component(s) that are involved. A number of cytosolic/nuclear PtdIns(4,5)P2-deficient Swiss 3T3 cell lines were established, and their G 0/G 1/S cell cycle phase transitions induced by defined mitogens were examined. Our results demonstrate that nuclear PtdIns(4,5)P2 down-regulation caused a delay in phorbol ester-induced S phase entry and that this was at least in part channeled through cyclin A2 at the transcriptional level. In summary, these data identify cyclin A2 as a downstream effector of the nuclear PtdIns(4,5)P2 signaling network and highlight the importance of nuclear PtdIns(4,5)P2 in the regulation of mammalian mitogenesis
AU - Ho,KK
AU - Anderson,AA
AU - Rosivatz,E
AU - Lam,EW
AU - Woscholski,R
AU - Mann,DJ
DO - 10.1074/jbc.M706623200
EP - 5485
PY - 2008///
SP - 5477
TI - Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network
T2 - J.Biol.Chem.
UR - http://dx.doi.org/10.1074/jbc.M706623200
UR - pm:18077453
VL - 283
ER -
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