In this section
@article{Wang:2012:10.1016/j.tim.2012.05.001,
author = {Wang, B and Buck, M},
doi = {10.1016/j.tim.2012.05.001},
journal = {Trends in Microbiology},
pages = {376--384},
title = {Customizing cell signaling using engineered genetic logic circuits},
url = {http://dx.doi.org/10.1016/j.tim.2012.05.001},
volume = {20},
year = {2012}
}
TY - JOUR
AB - Cells live in an ever-changing environment and continuously sense, process and react to environmental signals using their inherent signaling and gene regulatory networks. Recently, there have been great advances on rewiring the native cell signaling and gene networks to program cells to sense multiple noncognate signals and integrate them in a logical manner before initiating a desired response. Here, we summarize the current state-of-the-art of engineering synthetic genetic logic circuits to customize cellular signaling behaviors, and discuss their promising applications in biocomputing, environmental, biotechnological and biomedical areas as well as the remaining challenges in this growing field.
AU - Wang,B
AU - Buck,M
DO - 10.1016/j.tim.2012.05.001
EP - 384
PY - 2012///
SN - 0966-842X
SP - 376
TI - Customizing cell signaling using engineered genetic logic circuits
T2 - Trends in Microbiology
UR - http://dx.doi.org/10.1016/j.tim.2012.05.001
UR - http://www.cell.com/trends/microbiology/abstract/S0966-842X(12)00082-0
VL - 20
ER -
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