In this section
@article{Smyth:2017:10.1111/cei.12931,
author = {Smyth, LA and Meader, L and Xiao, F and Woodward, M and Brady, HJ and Lechler, R and Lombardi, G},
doi = {10.1111/cei.12931},
journal = {Clinical and Experimental Immunology},
pages = {219--225},
title = {Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance},
url = {http://dx.doi.org/10.1111/cei.12931},
volume = {188},
year = {2017}
}
TY - JOUR
AB - Anti-apoptotic genes, including those of the Bcl-2 family, have been shown to have dual functionality inasmuch as they inhibit cell death but also regulate inflammation. Several anti-apoptotic molecules have been associated with endothelial cell (EC) survival following transplantation; however, their exact role has yet to be elucidated in respect to controlling inflammation. In this study we created mice expressing murine A1 (Bfl-1), a Bcl-2 family member, under the control of the human intercellular adhesion molecule 2 (ICAM-2) promoter. Constitutive expression of A1 in murine vascular ECs conferred protection from cell death induced by the proinflammatory cytokine tumour necrosis factor (TNF)-α. Importantly, in a mouse model of heart allograft transplantation, expression of A1 in vascular endothelium increased survival in the absence of CD8(+) T cells. Better graft outcome in mice receiving an A1 transgenic heart correlated with a reduced immune infiltration, which may be related to increased EC survival and reduced expression of adhesion molecules on ECs. In conclusion, constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular ECs leads to prolonged allograft survival due to modifying inflammation.
AU - Smyth,LA
AU - Meader,L
AU - Xiao,F
AU - Woodward,M
AU - Brady,HJ
AU - Lechler,R
AU - Lombardi,G
DO - 10.1111/cei.12931
EP - 225
PY - 2017///
SN - 1365-2249
SP - 219
TI - Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance
T2 - Clinical and Experimental Immunology
UR - http://dx.doi.org/10.1111/cei.12931
UR - http://www.ncbi.nlm.nih.gov/pubmed/28120329
VL - 188
ER -
Interested in studying a PhD at the Department of Life Sciences? Find out more about postgraduate research opportunties.