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• Conference paper
  Akama TO, Nakayama J, Nakagawa H, Wong N, Sutton-Smith M, Nishimura S, Moremen KW, Dell A, Marth JD, Fukuda MNet al., 2004,

  Enzymatic activity of α-mannosidase IIx in <i>N</i>-glycan biosynthesis

  , Joint Meeting of the Society-for-Glycobiology/Japanese-Society-for-Carbohydrate-Research, Publisher: OXFORD UNIV PRESS INC, Pages: 1145-1145, ISSN: 0959-6658
  • Author Web Link
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  • Citations: 1
• Journal article
  Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR, Frankel G, Holden DW, Dougan Get al., 2004,

  <i>Salmonella enterica</i> serovar Typhimurium interaction with dendritic cells:: impact of the <i>sifA</i> gene

  , CELLULAR MICROBIOLOGY, Vol: 6, Pages: 1071-1084, ISSN: 1462-5814
  • Author Web Link
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  • Citations: 31
• Conference paper
  Davis DM, Önfelt B, Nedvetzki S, Vanherberghen B, McCann FE, Carlin LM, Taner SB, Eleme K, Treanor B, de Almeida C, Williams G, Nolte E, Hoen T, Yanagi Ket al., 2004,

  Membrane nanotubes network immune cells

  , Annual Meeting of the American-Society-for-Cell-Biology, Publisher: AMER SOC CELL BIOLOGY, Pages: 6A-6A, ISSN: 1059-1524
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• Conference paper
  Dell A, Stuton-Smith M, Goldberg D, Panico M, Chalabi S, Wong NK, Hitchen P, Jang-Lee JH, North Set al., 2004,

  MALDI and electrospray MS strategies for glycomics and glyco-proteomics.

  , Joint Meeting of the Society-for-Glycobiology/Japanese-Society-for-Carbohydrate-Research, Publisher: OXFORD UNIV PRESS INC, Pages: 1069-1069, ISSN: 0959-6658
  • Author Web Link
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• Journal article
  Önfelt B, Davis DM, 2004,

  Can membrane nanotubes facilitate communication between immune cells?

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 32, Pages: 676-678, ISSN: 0300-5127
  • Cite
  • Citations: 41
• Journal article
  Franks NP, Honoré E, 2004,

  The TREK K_2P channels and their role in general anaesthesia and neuroprotection

  , TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 25, Pages: 601-608, ISSN: 0165-6147
  • Cite
  • Citations: 174
• Journal article
  Mundy R, Jenkins C, Yu J, Smith H, Frankel Get al., 2004,

  Distribution of <i>espl</i> among clinical enterohaemorrhagic and enteropathogenic <i>Escherichia coli</i> isolates

  , JOURNAL OF MEDICAL MICROBIOLOGY, Vol: 53, Pages: 1145-1149, ISSN: 0022-2615
  • Cite
  • Citations: 42
• Journal article
  Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews Set al., 2004,

  (1)H, (13)C, and (15)N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E. coli (EPEC).

  , J Biomol NMR, Vol: 30, Pages: 387-388, ISSN: 0925-2738
  • Author Web Link
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• Journal article
  Dreveny I, Pye VE, Beuron F, Briggs LC, Isaacson RL, Matthews SJ, McKeown C, Yuan X, Zhang X, Freemont PSet al., 2004,

  P97 and close encounters of every kind: a brief review

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 32, Pages: 715-720, ISSN: 0300-5127
  • Cite
  • Citations: 67
• Journal article
  Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews Set al., 2004,

  Letter to the Editor: <SUP>1</SUP>H, <SUP>13</SUP>C, and <SUP>15</SUP>N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic <i>E-coli</i> (EPEC)

  , JOURNAL OF BIOMOLECULAR NMR, Vol: 30, Pages: 387-388, ISSN: 0925-2738
  • Cite
• Conference paper
  Goldberg D, North SJ, Sutton-Smith M, Haslam SM, Paulson J, Morris HR, Dell Aet al., 2004,

  Glycomics analyses: Automatic annotation of Maldi spectra

  , Joint Meeting of the Society-for-Glycobiology/Japanese-Society-for-Carbohydrate-Research, Publisher: OXFORD UNIV PRESS INC, Pages: 1189-1190, ISSN: 0959-6658
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• Journal article
  Davies TJ, Barraclough TG, Savolainen V, Chase MWet al., 2004,

  Environmental causes for plant biodiversity gradients

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 359, Pages: 1645-1656, ISSN: 0962-8436
  • Cite
  • Citations: 46
• Journal article
  Wigneshweraraj SR, Burrows PC, Nechaev S, Zenkin N, Severinov K, Buck Met al., 2004,

  Regulated communication between the upstream face of RNA polymerase and the β′ subunit jaw domain

  , EMBO JOURNAL, Vol: 23, Pages: 4264-4274, ISSN: 0261-4189
  • Cite
  • Citations: 28
• Journal article
  Burrows PC, Severinov K, Buck M, Wigneshweraraj SRet al., 2004,

  Reorganisation of an RNA polymerase-promoter DNA complex for DNA melting

  , EMBO JOURNAL, Vol: 23, Pages: 4253-4263, ISSN: 0261-4189
  • Cite
  • Citations: 33
• Journal article
  Sugiura M, Rappaport F, Brettel K, Noguchi T, Rutherford AW, Boussac Aet al., 2004,

  Site-directed mutagenesis of the <i>Thermosynechococcus elongatus</i> photosystem II: The O₂-evolving enzyme lacking the redox-active tyrosine D

  , BIOCHEMISTRY, Vol: 43, Pages: 13549-13563, ISSN: 0006-2960
  • Cite
  • Citations: 66
• Journal article
  Patel SD, Isalan M, Gavory G, Ladame S, Choo Y, Balasubramanian Set al., 2004,

  Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes

  , BIOCHEMISTRY, Vol: 43, Pages: 13452-13458, ISSN: 0006-2960
  • Cite
  • Citations: 43
• Journal article
  Davies TJ, Savolainen V, Chase MW, Moat J, Barraclough TGet al., 2004,

  Environmental energy and evolutionary rates in flowering plants

  , PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 271, Pages: 2195-2200, ISSN: 0962-8452
  • Cite
  • Citations: 179
• Journal article
  Wang HY, McCann FE, Gordan JD, Wu X, Raab M, Malik TH, Davis DM, Rudd CEet al., 2004,

  ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation

  , JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 200, Pages: 1063-1074, ISSN: 0022-1007
  • Cite
  • Citations: 80
• Journal article
  Smeulders MJ, Keer J, Gray KM, Williams HDet al., 2004,

  <i>S</i>-nitrosoglutathione cytotoxicity to <i>Mycobacterium smegmatis</i> and its use to isolate stationary phase survival mutants

  , FEMS MICROBIOLOGY LETTERS, Vol: 239, Pages: 221-228, ISSN: 0378-1097
  • Cite
  • Citations: 3
• Journal article
  Litt DJ, Savino S, Beddek A, Comanducci M, Sandiford C, Stevens J, Levin M, Ison C, Pizza M, Rappuoli R, Kroll JSet al., 2004,

  Putative vaccine antigens from <i>Neisseria meningitidis</i> recognized by serum antibodies of young children convalescing after meningococcal disease

  , JOURNAL OF INFECTIOUS DISEASES, Vol: 190, Pages: 1488-1497, ISSN: 0022-1899
  • Cite
  • Citations: 66
• Journal article
  Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart Wet al., 2004,

  Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.

  , Biochem Pharmacol, Vol: 68, Pages: 1621-1629, ISSN: 0006-2952

  The benzodiazepine binding site of GABA(A) receptors is located at the interface of the alpha and gamma subunits. Certain point mutations in these subunits have been demonstrated to dramatically reduce the affinity of benzodiazepine binding site ligands for these receptors. Recently, mice were generated with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit of GABA(A) receptors. Here we tested the potency of 24 benzodiazepine binding site ligands from 16 different structural classes for inhibition of [(3)H]flunitrazepam binding to brain membranes of these gamma2F77I mice. Results indicate that the potency of the classical 1,4-benzodiazepines, of the 1,4-thienodiazepine clotiazepam, the 1,5-benzodiazepine clobazam, or the pyrazoloquinoline CGS 9896 is only 2-7-fold reduced by this gamma2F77I point mutation. The potency of the imidazopyrimidines Ru 32698, Ru 33203, and Ru 33356, of the imidazoquinoline Ru 31719, or the pyrazolopyridine CGS 20625 is reduced 10-20-fold, whereas the potency of some imidazobenzodiazepines, beta-carbolines, cyclopyrrolones, imidazopyridines, triazolopyridazines, or quinolines is 100-1000-fold reduced. Interestingly, the extent of potency reduction induced by the gamma2F77I point mutation varied within the structural classes of compounds. Results support and significantly extend previous observations indicating that the residue gamma2F77 is important for high affinity binding of some, but not all benzodiazepine site ligands.

  • Abstract
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• Journal article
  Li CKF, Pender SLF, Pickard KM, Chance V, Holloway JA, Huett A, Gonçalves NS, Mudgett JS, Dougan G, Frankel G, MacDonald TTet al., 2004,

  Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice

  , JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 5171-5179, ISSN: 0022-1767
  • Cite
  • Citations: 55
• Conference paper
  Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart Wet al., 2004,

  Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA_A receptor γ2 subunit

  , 6th Decades of GABA Conference, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 1621-1629, ISSN: 0006-2952
  • Cite
  • Citations: 41
• Journal article
  Pazos F, Sternberg MJE, 2004,

  Automated prediction of protein function and detection of functional sites from structure

  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 14754-14759, ISSN: 0027-8424
  • Cite
  • Citations: 148
• Journal article
  Ma DQ, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze Met al., 2004,

  Dexmedetomidine produces its neuroprotective effect via the α_2A-adrenoceptor subtype

  , EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 502, Pages: 87-97, ISSN: 0014-2999
  • Cite
  • Citations: 238
• Journal article
  Kittel TGF, Rosenbloom NA, Royle JA, Daly C, Gibson WP, Fisher HH, Thornton P, Yates DN, Aulenbach S, Kaufman C, McKeown R, Bachelet D, Schimel DS, Neilson R, Lenihan J, Drapek R, Ojima DS, Parton WJ, Melillo JM, Kicklighter DW, Tian H, McGuire AD, Sykes MT, Smith B, Cowling S, Hickler T, Prentice IC, Running S, Hibbard KA, Post WM, King AW, Smith T, Rizzo B, Woodward FIet al., 2004,

  VEMAP Phase 2 bioclimatic database. I. Gridded historical (20th century) climate for modeling ecosystem dynamics across the conterminous USA

  , Climate Research, Vol: 27, Pages: 151-170, ISSN: 0936-577X

  Analysis and simulation of biospheric responses to historical forcing require surface climate data that capture those aspects of climate that control ecological processes, including key spatial gradients and modes of temporal variability. We developed a multivariate, gridded historical climate dataset for the conterminous USA as a common input database for the Vegetation/Ecosystem Modeling and Analysis Project (VEMAP), a biogeochemical and dynamic vegetation model intercomparison. The dataset covers the period 1895-1993 on a 0.5° latitude/longitude grid. Climate is represented at both monthly and daily timesteps. Variables are: precipitation, mininimum and maximum temperature, total incident solar radiation, daylight-period irradiance, vapor pressure, and daylight-period relative humidity. The dataset was derived from US Historical Climate Network (HCN), cooperative network, and snowpack telemetry (SNOTEL) monthly precipitation and mean minimum and maximum temperature station data. We employed techniques that rely on geostatistical and physical relationships to create the temporally and spatially complete dataset. We developed a local kriging prediction model to infill discontinuous and limited-length station records based on spatial autocorrelation structure of climate anomalies. A spatial interpolation model (PRISM) that accounts for physiographic controls was used to grid the infilled monthly station data. We implemented a stochastic weather generator (modified WGEN) to disaggregate the gridded monthly series to dailies. Radiation and humidity variables were estimated from the dailies using a physically-based empirical surface climate model (MTCLIM3). Derived datasets include a 100 yr model spin-up climate and a historical Palmer Drought Severity Index (PDSI) dataset. The VEMAP dataset exhibits statistically significant trends in temperature, precipitation, solar radiation, vapor pressure, and PDSI for US National Assessment regions. The historical climate an

  • Abstract
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  • Citations: 43
• Journal article
  Granés F, Roig MB, Brady HJM, Gil-Gómez Get al., 2004,

  Cdk2 activation acts upstream of the mitochondrion during glucocorticoid induced thymocyte apoptosis

  , EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 34, Pages: 2781-2790, ISSN: 0014-2980
  • Cite
  • Citations: 23
• Journal article
  Barboni D, Harrison SP, Bartlein PJ, Jalut G, New M, Prentice IC, Sanchez-Goñi MF, Spessa A, Davis B, Stevenson ACet al., 2004,

  Relationships between plant traits and climate in the Mediterranean region: A pollen data analysis

  , JOURNAL OF VEGETATION SCIENCE, Vol: 15, Pages: 635-646, ISSN: 1100-9233
  • Cite
  • Citations: 71
• Journal article
  Hay A, Barkoulas M, Tsiantis M, 2004,

  PINning down the connections: transcription factors and hormones in leaf morphogenesis

  , CURRENT OPINION IN PLANT BIOLOGY, Vol: 7, Pages: 575-581, ISSN: 1369-5266
  • Cite
  • Citations: 30
• Journal article
  Windbichler N, Schroeder R, 2004,

  Double duty

  , NATURE STRUCTURAL & MOLECULAR BIOLOGY, Vol: 11, Pages: 910-911, ISSN: 1545-9993
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