BibTex format
@article{Xie:2023:pnasnexus/pgad247,
author = {Xie, Y and Zhao, F and Freitag, N and Borowski, S and Wang, Y and Harms, C and Pang, P-C and Desforges, J and Wen, T and Schwedhelm, E and Singh, M and Dechend, R and Dell, A and Haslam, SM and Dveksler, G and Garcia, MG and Blois, SM},
doi = {pnasnexus/pgad247},
journal = {PNAS Nexus},
title = {Maternal-derived galectin-1 shapes the placenta niche through Sda terminal glycosylation: implication for preeclampsia},
url = {http://dx.doi.org/10.1093/pnasnexus/pgad247},
volume = {2},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (e.g. preeclampsia [PE]) with long-lasting consequences for the mother and offspring. The molecular dialogue between the maternal niche and the developing placenta is critical for the function of this organ. Galectin-1 (gal-1), a highly expressed glycan-binding protein at the maternal–fetal interface, orchestrates the maternal adaptation to pregnancy and placenta development. Down-regulation or deficiency of gal-1 during pregnancy is associated with the development of PE; however, the maternal- and placental-derived gal-1 contributions to the disease onset are largely unknown. We demonstrate that lack of gal-1 imposes a risk for PE development in a niche-specific manner, and this is accompanied by a placental dysfunction highly influenced by the absence of maternal-derived gal-1. Notably, differential placental glycosylation through the Sda-capped N-glycans dominates the invasive trophoblast capacity triggered by maternal-derived gal-1. Our findings show that gal-1 derived from the maternal niche is essential for healthy placenta development and indicate that impairment of the gal-1 signaling pathway within the maternal niche could be a molecular cause for maternal cardiovascular maladaptation during pregnancy.
AU - Xie,Y
AU - Zhao,F
AU - Freitag,N
AU - Borowski,S
AU - Wang,Y
AU - Harms,C
AU - Pang,P-C
AU - Desforges,J
AU - Wen,T
AU - Schwedhelm,E
AU - Singh,M
AU - Dechend,R
AU - Dell,A
AU - Haslam,SM
AU - Dveksler,G
AU - Garcia,MG
AU - Blois,SM
DO - pnasnexus/pgad247
PY - 2023///
SN - 2752-6542
TI - Maternal-derived galectin-1 shapes the placenta niche through Sda terminal glycosylation: implication for preeclampsia
T2 - PNAS Nexus
UR - http://dx.doi.org/10.1093/pnasnexus/pgad247
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001052640100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://doi.org/10.1093/pnasnexus/pgad247
UR - http://hdl.handle.net/10044/1/107483
VL - 2
ER -