Integral membrane proteins are critical components of all life: they are central to cell bioenergetics (both photosynthesis and respiration); act as cellular 'gatekeepers' for nutrient import and toxin export; and respond to the environment by mediating responses to a wide range of biologically active molecules -- including the majority of currently available drugs. Despite this central role, the hydrophobic nature of membrane proteins leaves them difficult to study, and our understanding of how they work usually lags behind our understanding of soluble proteins. Our research groups use a range of structural and biophysical tools to gain insights into the structure and mechanism of these important proteins.

Research groups