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Building the future of precision medicine for cardiomyopathies
The Sir Michael Uren Cardiomyopathy Innovation Centre brings together researchers, clinicians and data scientists from Imperial and its NHS partners to transform understanding of heart muscle disease and improve outcomes for patients.
While cardiomyopathies affect around one in 150 people, important questions remain about why patients with apparently similar diagnoses can experience very different disease progression, treatment responses and outcomes.
Supported by a £15.24 million gift from the Michael Uren Foundation, the Centre was established to tackle these unanswered questions and help lay the foundations for precision medicine approaches to diagnosis, risk prediction and treatment.
"Our vision is to improve understanding of disease heterogeneity, identify new biological drivers of cardiomyopathy and develop more precise approaches to diagnosis, risk prediction and treatment."
Main links list
Quick links
- Research Hubs
- Our Approach
- Collaborate
At a glance
1 in 150 people are affected by cardiomyopathy.
Patients with the same diagnosis can experience very different disease progression and outcomes.
More than 100 genes have been linked to inherited cardiomyopathies.
Up to 60% of cases have no identified cause.
Research Hubs
Clinical Studies and Genetics Hub
Led by Dr Paz Tayal, Professor Fu Siong Ng, Dr Brian Halliday, Professor James Ware, Professor Sanjay Prasad and Dr Amanda Varnava, this hub will recruit and study patients with cardiomyopathy, alongside individuals carrying disease-causing genetic variants.
Advanced Spatial Biology Hub
Led Professor Michela Noseda, Professor Manuel Mayr and Professor Steven Niederer, this hub will investigate the molecular and cellular changes that drive disease within the heart, using next-generation spatial biology technologies.
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Advanced Cardiac Imaging Hub
Led by Dr Sonia Nielles-Vallespin, Dr Brian Halliday, Professor Sanjay Prasad and Dr James Howard, this hub will develop imaging approaches that reflect the underlying biology of cardiomyopathy and support more personalised care.
Clinical Studies and Genetics Hub Co-Leads
Dr Paz Tayal
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Dr Paz Tayal
Professor Fu Siong Ng
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Professor Fu Siong Ng
Dr Brian Halliday
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Dr Brian Halliday
Professor James Ware
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Professor James Ware
Professor Sanjay Prasad
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Professor Sanjay Prasad
Dr Amanda Varnava
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Dr Amanda Varnava
Advanced Spatial Biology Hub Co-Leads
Professor Michela Noseda
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Professor Michela Noseda
Professor Manuel Mayr
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Professor Manuel Mayr
Professor Steve Niederer
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Professor Steve Niederer
Supported by the Michael Uren Foundation
The Sir Michael Uren Cardiomyopathy Innovation Centre has been established through a transformative gift from the Michael Uren Foundation. This support will enable the development of new research infrastructure, large-scale patient cohorts and collaborative research programmes aimed at accelerating progress in cardiomyopathy research and precision medicine.