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  • Journal article
    Mahmoudi M, Nicholas Z, Jabbour RJ, Shambrook J, Abbas A, Browne T, Hinton J, Antoniades C, Mamas M, Leipsic J, Rogers C, Koo B-K, Al-Lamee R, Kontopantelis E, Curzen Net al., 2026,

    Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study

    , AMERICAN HEART JOURNAL, Vol: 292, ISSN: 0002-8703
  • Journal article
    Hada M, Collet C, Storozhenko T, Munhoz D, Wilgenhof A, Gutierrez-Barrios A, de Vos A, Beleslin B, Berry C, Perera D, Rivero F, Bouisset F, Maria GLD, Karamasis G, Lonborg J, Escaned J, Ikeda K, Carson K, Konstantinou K, Mariathas M, Damman P, De Silva R, Al-Lamee R, Fournier S, Engstrom T, Keeble TR, Mizukami T, Gori T, Kakuta T, Paradies V, Pijls NHJ, Keulards D, De Bruyne Bet al., 2026,

    Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry

    , AMERICAN HEART JOURNAL, Vol: 291, Pages: 136-143, ISSN: 0002-8703
  • Conference paper
    Jevsikov J, Stowell CC, Ng T, Unsworth B, Zolgharni M, Francis DP, Manisty CH, Shun-Shin MJet al., 2026,

    Robustness of Human vs. AI Measurements Under Progressive Image Degradation

    , 2nd International Conference on Artificial Intelligence in Healthcare-AIiH, Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 261-268, ISSN: 0302-9743
  • Book chapter
    Fernandes P, Naidoo P, Ufumaka I, Adibzadeh S, Alajrami E, Jevsikov J, Dadashiserej N, Howar J, Shun-Shin M, Manisty C, Francis D, Zolgharni Met al., 2026,

    Deep Learning for Assessing Rotational Misalignment in Echocardiographic Imaging

    , Editors: Rittman, Ni, Cafolla, Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 269-282, ISBN: 978-3-032-00627-1
  • Book chapter
    Naidoo P, Fernandes P, Ufumaka I, Serej ND, Howard J, Francis D, Manisty C, Zolgharni Met al., 2026,

    Spatiotemporal Contrastive Learning for Echocardiography View Classification

    , Editors: Rittman, Ni, Cafolla, Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 247-260, ISBN: 978-3-032-00627-1
  • Journal article
    Rajendra S, Salmasi Y, Raj B, Dar O, Marczin N, Francis D, Khoshbin Eet al., 2025,

    Perioperative Predictors of Right Ventricular Failure Following Left Ventricular Assist Device Implantation.

    , ASAIO J

    Right ventricular failure (RVF) is an important complication following implantation of a left ventricular assist device (LVAD) in patients with advanced heart failure. This study aims to identify perioperative hemodynamic predictors of RVF following LVAD implantation and develop an internally validated predictive model. Patients who underwent LVAD implantations between March 2013 and March 2023 at a large-volume tertiary center were retrospectively analyzed. The primary outcome was early post-implant RVF, defined by need for right ventricular assist device (RVAD), prolonged inotrope dependence (> 14 days), or death within 14 days while on inotropes. Perioperative hemodynamic variables were analyzed using univariate logistic regression. A prediction model was then developed using stepwise multivariate logistic regression, and internally validated using k-fold cross-validation. Among 210 patients, 73 patients (34.8%) developed early post-implant RVF. Decreased post-implant cardiac index (odds ratio [OR]: 0.0122, p = 0.001), decreased mean arterial pressure (OR: 0.932, p = 0.008), and simultaneously increased cardiac index and pulmonary pulse pressure (OR: 1.13, p = 0.021) independently predicted RVF. Preimplantation IV inotrope therapy was a significant confounder (OR: 3.96, p = 0.021). Our proposed predictive model achieved strong discriminatory power (area under the curve [AUC] of 0.830) and stable cross-validation performance. External validation with multicenter cohorts is warranted to confirm predictive accuracy and clinical applicability.
  • Journal article
    Kose O, Sahal A, Zhang GK, Possik E, Fiuzat M, Psotka MA, Kao DP, Shalowitz E, Martyn T, Kittipibul V, Ni W, Tingley W, Vlajnic V, Abildstrøm SZ, Cowie M, Majmudar M, Ahmad T, Leifer E, Fudim M, O'Connor CM, Sharma Aet al., 2025,

    Framework for Analytical Validation of DHT-Based Actigraphy and Signal Measures in HF Trials: The VALIDATE-HF Program.

    , JACC Heart Fail
  • Journal article
    Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Chotai S, Simader FA, Mohsin M, Salih A, Ganesananthan S, Bual N, Petraco R, Nijjer SS, Sen S, Sehmi J, Ruparelia N, Dungu JN, Kabir A, Tang K, Gamma R, Davies JR, Kotecha T, Cole GD, Howard JP, Keeble TR, Clesham GJ, O'Kane PD, Harrell Jr FE, Francis DP, Shun-Shin MJ, Al-Lamee RKet al., 2025,

    The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study

    , CIRCULATION, Vol: 152, Pages: 1541-1551, ISSN: 0009-7322
  • Journal article
    Haworth PAJ, Bent C, Chapman N, Al-Lamee RK, Dasgupta I, McCormack T, Rahimi Ket al., 2025,

    Renal denervation for hypertension management in the UK: a Delphi expert consensus

    , HEART, ISSN: 1355-6037
  • Journal article
    Khialani B, Alfonso F, Malakouti S, Rodrigues ACLF, Reddy K, Garcia HM, Park S-J, Colombo A, Hernandez JMDLT, Al-Lamee R, Iwanczyk S, Stone G, Cortese Bet al., 2025,

    Preventive Percutaneous Intervention of Vulnerable Coronary Plaques

    , AMERICAN JOURNAL OF CARDIOLOGY, Vol: 255, Pages: 89-98, ISSN: 0002-9149
  • Conference paper
    Foley M, Mohsin M, Ahmed-Jushuf F, Rajkumar C, Chotai S, Simader F, Wang D, Davies J, Keeble T, Okane P, Kotecha T, Nijjer S, Petraco R, Khamis R, De Silva R, Jonathan H, Cosgrove C, Spratt J, Mikhail G, Cole G, Harrell F, Howard J, Francis D, Kellman P, Shun-Shin M, Al-Lamee Ret al., 2025,

    Endocardial to epicardial blood flow ratio predicts the placebo-controlled efficacy of the coronary sinus reducer

    , American-Heart-Association Scientific Sessions / American-Heart-Association Resuscitation Science Symposium, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
  • Journal article
    Monguillon V, Kelly P, O'Donoghue ML, Park J-G, Bohula EA, Saver JL, Atar D, Keech AC, Sever PS, Wang H, Paiva da Silva Lima G, Sabatine MS, Giugliano RPet al., 2025,

    Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke.

    , Circulation

    BACKGROUND: Patients with prior ischemic stroke are at high risk for recurrent stroke and other major adverse cardiovascular events (MACE). The benefits of achieving very low levels of low-density lipoproteins-cholesterol (LDL-C) in such patients is unclear. METHODS: We analyzed patients with prior ischemic stroke enrolled in FOURIER, a randomized placebo-controlled trial studying evolocumab in patients with stable atherosclerotic cardiovascular disease (median follow-up 2.2 years), and through the open-label extension (FOURIER-OLE) period (additional median follow-up 5 years), to examine the relationship between achieved LDL-C and the long-term incidence of the primary endpoint (cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina or coronary revascularization) and stroke-related endpoints. RESULTS: The analysis included 5,291 patients with prior ischemic stroke (more than 4 weeks old). A total of 666 (12.6%), 1410 (26.6%), 586 (11.1%), 508 (9.6%) and 2121 (40.1%) patients achieved LDL-C values of <20, 20 to <40, 40 to <55, 55 to <70 and ≥70 mg/dL, respectively. The incidence of the primary endpoint, all stroke, and ischemic stroke each decreased in a monotonic fashion with lower achieved LDL-C levels on a continuous scale (Ptrend <0.001, 0.002 and 0.002, respectively). Compared with patients with LDL-C ≥70 mg/dL, those who achieved levels <40 mg/dL had incidence rate ratios (IRRs) (95% CI) of 0.69 (0.57-0.84), 0.73 (0.53-0.99), and 0.75 (0.54-1.05) for the outcomes of the primary endpoint, all stroke, and ischemic stroke, respectively. Hemorrhagic strokes were infrequent and unrelated to achieved LDL-C (Ptrend=0.85). CONCLUSIONS: In patients with prior ischemic stroke, it appeared that the lower the LDL-C, down to levels below 40 mg/dL, the lower the risk of MACE, including recurrent stroke, without a clear increase in risk of hemorrhagic stroke. These findings support the concept that more intensive LDL-
  • Journal article
    Naidoo P, Fernandes P, Dadashi Serej N, Manisty CH, Shun-Shin MJ, Francis DP, Zolgharni Met al., 2025,

    Consensus-guided evaluation of self-supervised learning in echocardiographic segmentation.

    , Comput Biol Med, Vol: 198

    BACKGROUND: Left ventricle segmentation is a fundamental task in echocardiography, essential for assessing cardiac function. However, deep learning models for segmentation rely on large labelled datasets, which are expensive and time-consuming to annotate. Self-supervised learning has emerged as a promising approach to leverage unlabelled data, but its effectiveness for left ventricle segmentation remains underexplored. METHODS: This study investigates self-supervised learning for echocardiographic segmentation, comparing various pretext tasks. The impact of dataset size and distribution on pre-training is examined, revealing that excessive unlabelled data can degrade performance due to redundancy and low variability. A novel multi-expert labelled dataset is introduced to enhance segmentation evaluation, using consensus-based annotations to reduce annotation noise and improve reliability. RESULTS: Among the self-supervised learning methods evaluated, contrastive learning consistently outperforms other approaches, particularly in low-label settings. The study demonstrates that AI models pre-trained using self-supervised learning and fine-tuned with only 15% of labelled data achieve stronger alignment with multi-expert consensus than any individual expert. CONCLUSION: The findings suggest that AI models can generalise well across expert annotations, providing more reliable and reproducible assessments.
  • Journal article
    Chotai S, Chiew K, Al-Lamee R, 2025,

    Symptoms, coronary artery disease and percutaneous coronary intervention: connecting the dots

    , CURRENT OPINION IN CARDIOLOGY, Vol: 40, Pages: 417-423, ISSN: 0268-4705
  • Conference paper
    Rajkumar C, Foley M, Ahmed-Jushuf F, Chotai S, Simader F, Mohsin M, Salih A, Ganesananthan S, Nijjer S, Ruparelia N, Dungu J, Tang K, Davies J, Kotecha T, Howard J, Keeble T, Clesham G, O'kane P, Francis D, Shun-Shin MJ, Al-Lamee Ret al., 2025,

    The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study (ORBITA-STAR)

    , 37th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, ISSN: 0735-1097
  • Journal article
    Nijveldt R, Maeng M, Beijnink CWH, Piek JJ, Al-Lamee RK, Raposo L, Baptista SB, Escaned J, Davies J, Klem I, Yosofi B, van Geuns R-JM, Frederiksen CA, Jakobsen L, El Barzouhi A, van der Heijden DJ, Ilhan M, Rasoul S, Brinckman S, Saraber C, Jones DA, Petersen SE, Podlesnikar T, Bunc M, Beijk MAM, Piers LH, van Rees JB, Seligman H, Cole G, Iglesias JF, Degrauwe S, van 't Hof AWJ, Lipsic E, Pundziute-do Prado G, Chattranukulchai P, Rodriguez-Palomares JF, Rigger J, Meuwissen M, Kleijn L, Pereira B, Monti L, van der Schaaf RJ, Sanchis J, Belli G, Tijssen JGP, Thim T, van Royen Net al., 2025,

    Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction

    , NEW ENGLAND JOURNAL OF MEDICINE, ISSN: 0028-4793
  • Journal article
    Woehrle H, Wegscheider K, Simonds AK, Arzt M, Pepin J-L, Levy P, Heinzer R, Malhotra A, Cistulli P, Benjafield AV, Vettorazzi E, Cowie MRet al., 2025,

    Assessing new treatments for central sleep Apnoea in heart failure: sample size considerations for reliable detection of safety signals

    , SLEEP AND BREATHING, Vol: 29, ISSN: 1520-9512
  • Journal article
    Deharo F, Lyon AR, Thuny F, 2025,

    Non-bacterial thrombotic endocarditis in cancer

    , EUROPEAN HEART JOURNAL, ISSN: 0195-668X
  • Journal article
    Samways JW, Cheng T, Chow J-J, Shun-Shin MJ, Ali N, Keene D, Howard JP, Naraen A, Saleh K, Kaza N, Sharma C, Mohal JS, Reddy RK, Strocchi M, Niederer SA, Peters NS, Linton NWF, Kanagaratnam P, Ng FS, Francis DP, Whinnett ZI, Arnold ADet al., 2025,

    Ventricular repolarization is improved by His resynchronization therapy but not biventricular pacing.

    , Heart Rhythm

    BACKGROUND: Biventricular pacing (BVP) delivered cardiac resynchronization therapy (CRT) modestly improves activation synchrony in patients with heart failure and left bundle branch block (LBBB) but can trigger ventricular arrhythmias. His bundle pacing (HBP) can correct LBBB as an alternative CRT method, producing superior ventricular activation synchrony and hemodynamics. OBJECTIVE: The aim of the study was to investigate the relative effects of HBP-CRT and BVP-CRT on ventricular repolarization. METHODS: Patients with LBBB referred for BVP-CRT underwent intra-procedural non-invasive epicardial mapping during atrial pacing (intrinsic LBBB), BVP-CRT, and temporary HBP. When HBP corrected LBBB, changes from baseline (LBBB) in overall and left ventricular (LV) repolarization dispersion (ΔVRT, ΔLVRT), repolarization gradient (ΔVRG, ΔLVRG) and activation-recovery interval (ARI) dispersion (ΔVARI, ΔLVARI) were measured. RESULTS: 17 patients had full datasets. BVP-CRT had no effect on global repolarization dispersion, gradient steepness or ARI (ΔVRT -1.5 ms, 95% confidence interval [CI] -15.4 to +12.4, P = .82; ΔVRG -0.00549 ms/mm, -0.106 to +0.0954, P = .9; ΔVARI -5.0 ms, -24.3 to +14.3, P = .59) and worsened the parameters in the LV (ΔLVRT +14.5 ms, +0.05 to +28.9, P = .049; ΔLVRG +0.0931 ms/mm, -0.0635 to +0.25, P = .226, ΔLVARI +28.6 ms, 95% CI +6.0 to +51.2, P = .02). HBP-CRT significantly improved global repolarization dispersion, gradient steepness and ARI (ΔLVRT +14.5 ms, +0.05 to +28.9, P = .049; ΔLVRG +0.0931 ms/mm, -0.0635 to +0.25, P = .226; ΔVARI -49.5 ms, -69.0 to -29.9, P < .0001) and within the LV (ΔLVRT -38.2 ms, -48.7 to -27.6, P < .001; ΔLVRG -0.228 ms/mm, -0.334 to -0.122, P = .0003; ΔLVARI -37.2 ms, -59.4 to -15.0, P = .003). CONCLUSION: HBP-CRT improves LBBB-induced repolarization abnormalities through improved activation synchrony and AR
  • Journal article
    Krychtiuk KA, Lopes RD, Cargill VA, Chen R, Cowie MR, Cushman WC, Elkind MSV, Epstein S, Garg PP, Gersh BJ, Giakoumis M, Green JB, Guo W, Kirtane AJ, Lefkowitz M, Lesogor A, Mensah GA, O'Donoghue ML, Ohman EM, Pagidipati NJ, Reboussin D, Roessig L, Roger VL, Sanchez E, Stockbridge N, Touyz RM, Van Spall HGC, Weber MA, Whelton SP, Hernandez AF, Yancy CW, Granger CBet al., 2025,

    Overcoming Barriers to Developing and Implementing Novel Therapies for Hypertension

    , HYPERTENSION, Vol: 82, Pages: 1599-1611, ISSN: 0194-911X
  • Journal article
    Al-Lamee R, Chotai S, 2025,

    The Persistent Family Feud: CABG Versus PCI. Do We Even Need a Winner?

    , CIRCULATION, Vol: 152, Pages: 859-861, ISSN: 0009-7322
  • Journal article
    Nakayama M, Foley M, Rajkumar CA, Howard JP, Francis DP, Shun-Shin MJ, Iwasaki K, Matsuo H, Al-Lamee R, Warisawa Tet al., 2025,

    Reproducibility, Accuracy, and Treatment Impact of Ischemia Severity Assessment From Coronary Angiography ― An ORBITA Study Analysis ―

    , CIRCULATION REPORTS
  • Journal article
    Murugiah K, Shun-Shin MJ, Al-Lamee RK, 2025,

    Twists and Turns on the Road to Angina Relief

    , JACC-JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 86, Pages: 794-796, ISSN: 0735-1097
  • Journal article
    Murray-Thomas T, Bottle A, Mayet J, Myles Pet al., 2025,

    Non-adherence to medications prescribed to patients with heart failure in general practice: prevalence, risk factors and association with mortality and hospitalisation

    , OPEN HEART, Vol: 12, ISSN: 2053-3624
  • Journal article
    Ekmejian A, Allahwala U, Bahl R, Sen S, Petraco R, Ward M, Bhindi Ret al., 2025,

    Impact of Epicardial plaQUe Composition and geomeTry on Coronary hEmodynamics and Flow in Patients With Coronary Artery Disease (iEquate)

    , CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, ISSN: 1522-1946

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