BibTex format
@article{Delamare:2024:10.1016/j.jhepr.2024.101064,
author = {Delamare, H and Ishii-Rousseau, JE and Rao, A and Cresta, M and Vincent, JP and Ségéral, O and Nayagam, S and Shimakawa, Y},
doi = {10.1016/j.jhepr.2024.101064},
journal = {JHEP Rep},
title = {Proportion of pregnant women with HBV infection eligible for antiviral prophylaxis to prevent vertical transmission: A systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1016/j.jhepr.2024.101064},
volume = {6},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND & AIMS: In 2020, the World Health Organization (WHO) recommended peripartum antiviral prophylaxis (PAP) for pregnant women infected with hepatitis B virus (HBV) with high viremia (≥200,000 IU/ml). Hepatitis B e antigen (HBeAg) was also recommended as an alternative when HBV DNA is unavailable. To inform policymaking and guide the implementation of prevention of mother-to-child transmission strategies, we conducted a systematic review and meta-analysis to estimate the proportion of HBV-infected pregnant women eligible for PAP at global and regional levels. METHODS: We searched PubMed, EMBASE, Scopus, and CENTRAL for studies involving HBV-infected pregnant women. We extracted proportions of women with high viremia (≥200,000 IU/ml), proportions of women with positive HBeAg, proportions of women cross-stratified based on HBV DNA and HBeAg, and the risk of child infection in these maternal groups. Proportions were pooled using random-effects meta-analysis. RESULTS: Of 6,999 articles, 131 studies involving 71,712 HBV-infected pregnant women were included. The number of studies per WHO region was 66 (Western Pacific), 21 (Europe), 17 (Africa), 11 (Americas), nine (Eastern Mediterranean), and seven (South-East Asia). The overall pooled proportion of high viremia was 21.27% (95% CI 17.77-25.26%), with significant regional variation: Western Pacific (31.56%), Americas (23.06%), Southeast Asia (15.62%), Africa (12.45%), Europe (9.98%), and Eastern Mediterranean (7.81%). HBeAg positivity showed similar regional variation. After cross-stratification, the proportions of high viremia and positive HBeAg, high viremia and negative HBeAg, low viremia and positive HBeAg, and low viremia and negative HBeAg were 15.24% (95% CI 11.12-20.53%), 2.70% (95% CI 1.88-3.86%), 3.69% (95% CI 2.86-4.75%), and 75.59% (95% CI 69.15-81.05%), respectively. The corresponding risks of child infection following birth dose vaccination without immune globulin and PAP were 14.86% (95% C
AU - Delamare,H
AU - Ishii-Rousseau,JE
AU - Rao,A
AU - Cresta,M
AU - Vincent,JP
AU - Ségéral,O
AU - Nayagam,S
AU - Shimakawa,Y
DO - 10.1016/j.jhepr.2024.101064
PY - 2024///
TI - Proportion of pregnant women with HBV infection eligible for antiviral prophylaxis to prevent vertical transmission: A systematic review and meta-analysis.
T2 - JHEP Rep
UR - http://dx.doi.org/10.1016/j.jhepr.2024.101064
UR - https://www.ncbi.nlm.nih.gov/pubmed/39035070
VL - 6
ER -