Citation

BibTex format

@article{Bonell:2024:10.1016/S2542-5196(24)00208-0,
author = {Bonell, A and Vicedo-Cabrera, AM and Moirano, G and Sonko, B and Jeffries, D and Moore, SE and Haines, A and Prentice, AM and Murray, KA},
doi = {10.1016/S2542-5196(24)00208-0},
journal = {Lancet Planet Health},
pages = {e734--e743},
title = {Effect of heat stress in the first 1000 days of life on fetal and infant growth: a secondary analysis of the ENID randomised controlled trial.},
url = {http://dx.doi.org/10.1016/S2542-5196(24)00208-0},
volume = {8},
year = {2024}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: The intersecting crises of climate change, food insecurity, and undernutrition disproportionately affect children. Understanding the effect of heat on growth from conception to 2 years of age is important because of mortality and morbidity implications in the near term and over the life course. METHODS: In this secondary analysis, we used longitudinal pregnancy cohort data from the Early Nutrition and Immunity Development (ENID) randomised controlled trial in West Kiang, The Gambia, which occurred between Jan 20, 2010, and Feb 10, 2015. The ENID trial assessed micronutrient supplementation in the first 1000 days of life starting from 20 weeks' gestation, during which anthropometric measurements were collected prospectively. We used multivariable linear regression to assess the effect of heat stress (defined by Universal Thermal Climate Index [UTCI]) on intrauterine growth restriction based on length-for-gestational age Z score (LGAZ), weight-for-gestational age Z score (WGAZ), and head circumference-for-gestational age Z score (HCGAZ) at birth, and assessed for effect modification of supplement intervention on the relationship between heat stress and infant anthropometry. We used multivariable, multilevel linear regression to evaluate the effect of heat stress on infant growth postnatally based on weight-for-height Z score (WHZ), weight-for-age Z score (WAZ), and height-for-age Z score (HAZ) from 0 to 2 years of age. FINDINGS: Complete data were available for 668 livebirth outcomes (329 [49%] female infants and 339 [51%] male infants). With each 1°C increase in mean daily maximum UTCI exposure, in the first trimester, we observed a reduction in WGAZ (-0·04 [95% CI -0·09 to 0·00]), whereas in the third trimester, we observed an increase in HCGAZ (0·06 [95% CI 0·00 to 0·12]), although 95% CIs included 0. Maternal protein-energy supplementation in the third trimester was associated with reduced WGAZ (-0·1
AU - Bonell,A
AU - Vicedo-Cabrera,AM
AU - Moirano,G
AU - Sonko,B
AU - Jeffries,D
AU - Moore,SE
AU - Haines,A
AU - Prentice,AM
AU - Murray,KA
DO - 10.1016/S2542-5196(24)00208-0
EP - 743
PY - 2024///
SP - 734
TI - Effect of heat stress in the first 1000 days of life on fetal and infant growth: a secondary analysis of the ENID randomised controlled trial.
T2 - Lancet Planet Health
UR - http://dx.doi.org/10.1016/S2542-5196(24)00208-0
UR - https://www.ncbi.nlm.nih.gov/pubmed/39393375
VL - 8
ER -

Contact us


For any enquiries related to the MRC Centre please contact:

Scientific Manager
Susannah Fisher
mrc.gida@imperial.ac.uk

External Relationships and Communications Manager
Dr Sabine van Elsland
s.van-elsland@imperial.ac.uk