In this section
@article{Lai:2025,
author = {Lai, H and Soreq, E and Bourke, N and Baker, C and Zimmerman, K and Parkinson, M and Daniels, S and Gregg, E and Sharp, D and Li, L},
journal = {Age and Ageing},
title = {Traumatic brain injury (TBI) and mortality in older adults with and without pre-injury dementia},
year = {2025}
}
TY - JOUR
AB - Background: Incidence of traumatic brain injury (TBI) is rising in older adults. Dementia is a common comorbidity and may worsen post-TBI outcomes, but its effects have not been studied. Objective: To compare all-cause mortality following TBI or non-TBI trauma (NTT) and quantify the impacts of age, deprivation, and dementia.Design: Population-based retrospective cohort studySetting: Linked primary and secondary care electronic health records (EHRs) from the Secure Anonymised Information Linkage (SAIL) DatabankSubjects: Adult residents in Wales aged 18-100 with hospitalised TBI or NTT recorded between January 2000-December 2022. Methods: Cox proportional hazard models were used to estimate survival within 1, 6, and 12 months of hospitalised TBI/NTT in those with and without pre-injury dementia diagnosis. Groups were propensity-matched by age, sex, and morbidities. Models were stratified by age, sex, and deprivation.Results: 23,428 TBIs (n=18,940) and 589,169 NTTs (n=421,259) were identified. TBIs were associated with higher mortality than NTT at all timepoints. Older age was associated with higher mortality after TBI, with 16.9% one-month mortality in patients aged 65-79, and 31% in patients aged 80-100.In TBI patients, 30-day mortality was significant irrespective of dementia. 6- and 12-month mortality were higher in those with than without pre-injury dementia diagnosis. Conclusions: TBI is associated with higher all-cause mortality than NTT, particularly in older age. Among those with TBI, patients with pre-injury dementia had particularly high chronic mortality. There is an urgent need to understand the reasons for poor outcomes in older adult TBI populations, especially those with dementia.
AU - Lai,H
AU - Soreq,E
AU - Bourke,N
AU - Baker,C
AU - Zimmerman,K
AU - Parkinson,M
AU - Daniels,S
AU - Gregg,E
AU - Sharp,D
AU - Li,L
PY - 2025///
SN - 0002-0729
TI - Traumatic brain injury (TBI) and mortality in older adults with and without pre-injury dementia
T2 - Age and Ageing
ER -
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