Gynaecological cancer - surgery and translational research
Contact
Group lead
Professor Christina Fotopoulou
c.fotopoulou@imperial.ac.uk
Related themes
Disease areas
What we do
Our reseach focuses on (1) Intratumoral tumor heterogeneity in advanced epithelial ovarian cancer, (2) predicting surgical outcome in ovarian cancer surgery, and (3) implementing novel bioengineering advances in surgical success in ovarian cancer surgery.
Why it is important
Epithelial ovarian-cancer (EOC) is a heterogeneous disease with a high risk of development of platinum resistance conferring poor prognosis. A major challenge is the extensive intratumoral heterogeneity constituting a significant obstacle to the success of systemic and surgical therapeutic regimes. Our aim is to identify patterns of heterogeneity and correlate it with genomic profiling and recent bioengineering advances.
How it can benefit patients
By elucidating and defining the patterns of dissemination, relapse and resistance of epithelial ovarian cancer and stratifying patients to the treatment modalities that will truly benefit them. We are also directing patients who won't benefit from conventional treatment approaches to alternative strategies.
Summary of current research
- Intratumoral heterogeneity study
- Bioelectical potential study
- Lymphatics Project
- Identifying the genetic profile of "extreme" responders and non-responders
- Clinical research of surgical outcome
Connections
Funders
Collaborators
- James Moore, Professor of Bioengineering
- Martyn Boutelle, Professor of Bioengineering
- David Bowtell, Mac Callum Cancer Centre (Australia)
- Gordon Mills, MD Anderson Cancer Centre (USA)
For patients
PhD students
When we have funding for PhD studentships, we advertise them through central channels such as Find a PhD. Information is also available on the Surgery and Cancer study page. If no studentships are currently advertised, please get in touch with the group lead with proposed project titles to discuss further.
Current PhD students:
- Ratri Wulandari
- Katherine Nixon
- Haonan Lu
Our researchers
Professor Martyn G Boutelle
Professor Martyn G Boutelle
Associate Provost (Estates Planning)
Dr Paula Cunnea
Dr Paula Cunnea
Advanced Research Fellow
Professor Emm Mic Drakakis DUGS/DOCs
Professor Emm Mic Drakakis DUGS/DOCs
Professor of Bio-Circuits and Systems
Professor Christina Fotopoulou
Professor Christina Fotopoulou
Chair in Gynaecological Cancer Surgery
Dr Sally Gowers
Dr Sally Gowers
Research Associate
Professor James E Moore Jr
Professor James E Moore Jr
The Bagrit & RAEng Chair in Medical Device Design