Research Associate Genomics

Job summary

The position of Research Associate has become available in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/) to investigate mechanisms of human DNA replication and their misregulation in cancer employing biochemical & structural or genomic approaches. The current group consists of 11 researchers, including 6 postdocs, 4 students and one technician. The successful candidates will enjoy intensive...

Job listing information

  • Reference MED02738
  • Date posted 21 September 2021
  • Closing date 2 November 2021

Job description

Job summary

The position of Research Associate has become available in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/) to investigate mechanisms of human DNA replication and their misregulation in cancer employing biochemical & structural or genomic approaches.

The current group consists of 11 researchers, including 6 postdocs, 4 students and one technician. The successful candidates will enjoy intensive interactions with group members specialised in cryo-EM, biochemistry, high resolution genomic (ChIP-Exo) and proteomic (ChIP-MS) approaches generating a collaborative and highly productive atmosphere. We are excellent equipped for biochemistry (2 AKTA’s, 4 temperature-controlled shakers, 2 freezer mills, Constant System French Press, Biacore T100), structural EM work (cryo-EM facility with Talos 200kV FEG cryo-EM Falcon 3, Vitrobot IV, Leica GP2, GPU- and data storage-cluster and direct access to a Titan Krios with K3 detector as founding member of the LonCEN consortium) and genomics/proteomics (direct access to excellent local sequencing, genomics and proteomics facilities and bioinformatics team).

By joining the group, the candidates will not only participate in high profile research projects but will also be directly mentored by Professor Speck in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.

Duties and responsibilities

GENOMICS (1 Position)

Advances in genomics and proteomics have made it possible to marry up genomic with proteomic and structural data. Crucially, now it is possible to obtain information on protein complex location and size at a base pair resolution in a genome-wide manner generating high-resolution data in cells for the first time. The successful applicant will employ high resolution genomics (ChIP-Exo or Cut&Run), proteomic (ChIP-MS – training can be provided) and cell biological approaches to discover novel mechanisms in the function of human DNA replication origins and explore how misregulation of replication origins leads to genomic instability. Expertise in high-resolution genomics and bioinformatic analysis of data is essential.

The Research Associate will collaborate extensively as part of the overall project and work together with 3 PhD students investigating related, but not overlapping questions.

Essential requirements


  • Research Associate: Hold a PhD (or equivalent) in Biochemistry, Genetics or a closely related discipline

  • Research Assistant: Near completion of a PhD (or equivalent) in Biochemistry, Genetics, or a closely related discipline

  • At least one first-author publication in a high-quality peer-reviewed journal (published or submitted)

  • You should be highly ambitious and will aim to develop and publish major research projects

  • Strong expertise in genomics (ideally ChIP Exo or Cut&Run)

Further information

This is a Full Time & Fixed Term posts for 36 months with a possibility of extension, based at the Hammersmith Campus, London.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

 

Should you require any further details on the role please contact: Christian Speck – chris.speck@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

 

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.