Research Associate in Protein X-ray crystallography

Job summary

Salary Range: £37,904 to £45,547 per annum The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 (Times Higher Education), scoring 100% on our environment. We are seeking to recruit an outstanding structural biologist to contribute to an ongoing drug discovery project in the groups of Dr Ernesto Cota, Department of Life Sciences and Professor Edward Tate,...

Job listing information

  • Reference NAT00254
  • Date posted 16 August 2018
  • Closing date 16 September 2018

Job description

Job summary

Salary Range: £37,904 to £45,547 per annum

The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 (Times Higher Education), scoring 100% on our environment.

We are seeking to recruit an outstanding structural biologist to contribute to an ongoing drug discovery project in the groups of Dr Ernesto Cota, Department of Life Sciences and Professor Edward Tate, Department of Chemistry funded by Cancer Research UK. The project focuses on structure-guided design of ligands against small GTPases, a validated but challenging set of targets. The research is backed by a robust combination of biophysical, biochemical and cellular assays. The project is supported by collaborations with structural and cell biologists at Imperial and the CRUK Beatson Institute (Glasgow).

You will be expected to take a leading role in fragment-based screening, in silico design, protein X-ray crystallography, protein- and ligand-based NMR, and biophysical (ITC, SPR, MST) and biochemical assays, integrating data generated by colleagues working on hit optimisation and hit-to-lead programmes using medicinal chemistry approaches. You will exploit both small molecule and peptide modalities as appropriate to the target class, and will take responsibility for mentoring junior biochemists/structural biologists in our research teams.

Duties and responsibilities

• To take responsibility for the day-to-day running of biochemical/structural research of the project on small GTPases.
• To carry out the design and execution of appropriate experiments based on high-level research goals.
• To manage and mentor small teams of more junior colleagues and support learning in your field of expertise in order to maximise research productivity
• To report to regular laboratory meetings and project team meetings, and deliver presentations at internal and external seminars.
• To produce accurate report-ready data and to assist in the preparation of written progress reports and publications as required.

Essential requirements

You must have:
• A PhD (or equivalent), preferably in protein x-ray crystallography.
• A strong research track record in protein X-ray structure determination preferably demonstrated by first author publications in international journals.
• Experience in the design and execution of workflow for structure determination of proteins, from molecular biology/biochemical experiments
• Experience in optimisation of protein-ligand interactions using biophysical techniques

You must also have:
• Excellent verbal and written communication skills, and be able to write clearly and succinctly for publication.
• Ability to relate well with others, form positive relationships with a wide range of people and to work as part of a team, as well as independently.
• Ability to develop and apply new concepts and have a creative approach to problem-solving

Further information

Assistant within the salary range £33,380 - £35,061 per annum.

This is a full-time, fixed-term appointmentavailable for up to 12 months.

Informal enquires can be made directly to Dr Ernesto Cota, Senior Lecturer in Department of Life Sciences, at e.cota@imperial.ac.uk.

Should you have any queries regarding the application process please contact Miss Laila Pastor at l.pastor@imperial.ac.uk, to request an application form.

For technical queries during the application process, please contact recruitment@imperial.ac.uk

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.