Research Associate in Structural Biology of the Membrane Attack Complex

Job summary

Two Research Associates with expertise in structural biology, and in membrane biophysics are sought. Joining a collaborative research team with the Bubeck lab at Imperial College London and the Wallace lab at King’s College London we aim to uncover how the membrane attack complex (MAC) kills bacterial pathogens in the context of the cell envelope.

Job listing information

  • Reference NAT01088
  • Date posted 26 April 2022
  • Closing date 24 May 2022

Job description

Job summary

Two Research Associates with expertise in structural biology, and in membrane biophysics are sought. Joining a collaborative research team with the Bubeck lab at Imperial College London and the Wallace lab at King’s College London we aim to uncover how the membrane attack complex (MAC) kills bacterial pathogens in the context of the cell envelope.

Duties and responsibilities

Funded by a five year Wellcome Trust Investigator Award, the project’s objectives are to discover (1) where MAC is located within the bacterial envelope and (2) how MAC activation controls bacterial killing. You will join an exciting interdisciplinary team of structural biologists and membrane biophysicists to tackle this major outstanding question in understanding host-pathogen interactions. Linking cryo electron tomography and superresolution studies of MAC within the context of a series of novel mimics of the Gram-negative cell envelope, the research builds on a combined track-record in complement structural biology and artificial membranes.

Essential requirements

Research Associate 1 (Research Associate in Structural Biology of the Membrane Attack Complex),  based in the Bubeck lab at Imperial College London, will hold a PhD (or equivalent) in structural biology, ideally with experience in cellular tomography. You must have a strong research track record in studying protein-protein and protein-membrane complexes preferably demonstrated by first author publications in international journals. Experience in the design and execution of workflow for structure determination of proteins or cellular systems from sample preparation to acquisisation and analysis of structural biology data. Additional expertise in microbiology is very suited for the position. This is a full-time, fixed-term appointment available for up to 36 months. Please see the attached Job Description and Person Specification for the full list of requirements.

Research Associate 2 (Research Associate in Artificial Cell Envelopes) based in the Wallace lab at King’s College London will focus on building new artificial and biohybrid models of the gram-negative cell envelope, compatible with single-molecule and superresolution fluorescence imaging and cryo electron tomography. You will hold a PhD (or equivalent) in membrane biophysics, optical microscopy or multiphase microfluidics. Experience in artificial membranes, superresolution microscopy, microbiology, and microfluidics are desirable. This is a full-time, fixed-term appointment available for up to 48 months.

Both posts require excellent verbal and written communication skills, and be able to write clearly and succinctly for publication. You must also be able to relate well with others, form positive relationships with a wide range of people and to work as part of a team, as well as independently. The ability to develop and apply new concepts, have a creative approach to problem-solving, and to set and attain research objectives in a multidisciplinary team are also essential.

Further information

For further information on Research Associate 2 position based at Kings College London, and to apply, please visit: https://jobs.kcl.ac.uk/gb/en/job/044945/Research-Associate-in-Artificial-Cell-Envelopes.

 

Further information for Research Associate 1 based at Imperial College London:

  • The successful candidate appointed to the Bubeck lab at Imperial College London will be based at South Kensington Campus. This is a full-time, fixed-term appointment available for up to 36 months.
  • Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range, £36,694- £39,888 per annum.
  • Candidates interested in applying for Research 1 at Imperial College London should submit an application via the Imperial College London careers site. Please complete an application form as directed, also providing your CV and list of publications.

Informal enquiries to Dr. Doryen Bubeck (d.bubeck@imperial.ac.uk, https://www.imperial.ac.uk/people/d.bubeck) and Prof. Mark Wallace (mark.wallace@kcl.ac.uk, markwallace.org)

 

Committed to equality and valuing diversity. The Department of Life Sciences was awarded an Athena Swan Bronze Award. The Department of Chemistry is an Athena Gold Swan Award Winner. We are a Stonewall Diversity Champion, a Two Ticks Employer and are working in partnership with GIRES to promote respect for trans people.

Please note the College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

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About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

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