BibTex format
@article{Mountain:2025:10.1038/s41522-025-00783-x,
author = {Mountain, K and MacIntyre, D and Lee, Y and Tajadura-Ortega, V and Dell, A and Haslam, S and Wu, G and Grassi, P and Feizi, T and Liu, Y and Chai, W and Marchesi, J and Roberts, L and Chan, D and Gimeno-Molina, B and Brown, R and Lewis, H and Hyde, A and Pasint-Magyar, J and Green, A and David, A and Norman, J and Stock, S and Kundu, S and Ng, S and Glampson, B and Mayer, E and Teoh, T and Terzidou, V and Bennett, P and Sykes, L},
doi = {10.1038/s41522-025-00783-x},
journal = {npj Biofilms and Microbiomes},
title = {ABO blood group antigens influence host-microbe interactions and risk of early spontaneous preterm birth},
url = {http://dx.doi.org/10.1038/s41522-025-00783-x},
volume = {11},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (n=596) and immune profiling (n=314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal milieu. In contrast, women of blood group A have a higher prevalence of vaginal Lactobacillus crispatus, a lower risk of sPTB, with sPTB cases showing no association with vaginal microbiota composition or inflammation. We found that cervicovaginal fluid contains ABH(O) glycans, and show variable binding to key vaginal bacteria. This indicates that cervicovaginal ABH(O) glycans influence microbiota-host interactions implicated in sPTB risk, suggesting a novel target for sPTB prediction and prevention.
AU - Mountain,K
AU - MacIntyre,D
AU - Lee,Y
AU - Tajadura-Ortega,V
AU - Dell,A
AU - Haslam,S
AU - Wu,G
AU - Grassi,P
AU - Feizi,T
AU - Liu,Y
AU - Chai,W
AU - Marchesi,J
AU - Roberts,L
AU - Chan,D
AU - Gimeno-Molina,B
AU - Brown,R
AU - Lewis,H
AU - Hyde,A
AU - Pasint-Magyar,J
AU - Green,A
AU - David,A
AU - Norman,J
AU - Stock,S
AU - Kundu,S
AU - Ng,S
AU - Glampson,B
AU - Mayer,E
AU - Teoh,T
AU - Terzidou,V
AU - Bennett,P
AU - Sykes,L
DO - 10.1038/s41522-025-00783-x
PY - 2025///
SN - 2055-5008
TI - ABO blood group antigens influence host-microbe interactions and risk of early spontaneous preterm birth
T2 - npj Biofilms and Microbiomes
UR - http://dx.doi.org/10.1038/s41522-025-00783-x
VL - 11
ER -